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Pachamuthu Kandasamy

Showing results (1-10 of 16) with videos related to

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Journal of Medicinal Chemistry|April 27, 2007
Structure-based design, synthesis, and A-site rRNA cocrystal complexes of functionally novel aminoglycoside antibiotics: C2" ether analogues of paromomycinStephen Hanessian, Janek Szychowski, Susanta Sekhar Adhikari, et al.
ACS Chemical Biology|January 17, 2022
Quantitative Measurement of Cytosolic and Nuclear Penetration of Oligonucleotide TherapeuticsKirsten Deprey, Nefeli Batistatou, Marjoke F Debets, et al.
Translational Vision Science & Technology|January 29, 2021
Stereochemistry Enhances Potency, Efficacy, and Durability of <i>Malat1</i> Antisense Oligonucleotides In Vitro and In Vivo in Multiple SpeciesMichael Byrne, Vinod Vathipadiekal, Luciano Apponi, et al.
ACS Chemical Biology|March 3, 2015
siRNA conjugates carrying sequentially assembled trivalent N-acetylgalactosamine linked through nucleosides elicit robust gene silencing in vivo in hepatocytesShigeo Matsuda, Kristofer Keiser, Jayaprakash K Nair, et al.
Nature Communications|February 9, 2021
Variant-selective stereopure oligonucleotides protect against pathologies associated with C9orf72-repeat expansion in preclinical modelsYuanjing Liu, Jean-Cosme Dodart, Helene Tran, et al.
Journal of Medicinal Chemistry|February 9, 2023
Metabolically Stable Anomeric Linkages Containing GalNAc-siRNA Conjugates: An Interplay among ASGPR, Glycosidase, and RISC PathwaysPachamuthu Kandasamy, Shohei Mori, Shigeo Matsuda, et al.
Nucleic Acids Research|August 16, 2024
Rational design of base, sugar and backbone modifications improves ADAR-mediated RNA editingGenliang Lu, Chikdu Shivalila, Prashant Monian, et al.
Nucleic Acids Research|April 18, 2023
Impact of stereopure chimeric backbone chemistries on the potency and durability of gene silencing by RNA interferenceWei Liu, Naoki Iwamoto, Subramanian Marappan, et al.
Journal of the American Chemical Society|December 2, 2014
Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits robust RNAi-mediated gene silencingJayaprakash K Nair, Jennifer L S Willoughby, Amy Chan, et al.
Molecular Therapy : the Journal of the American Society of Gene Therapy|June 27, 2013
Biodegradable lipids enabling rapidly eliminated lipid nanoparticles for systemic delivery of RNAi therapeuticsMartin A Maier, Muthusamy Jayaraman, Shigeo Matsuda, et al.
Pageof 2

Showing results (1-10 of 16) with videos related to

Sort By:
Pageof 2
Journal of Medicinal Chemistry|April 27, 2007
Structure-based design, synthesis, and A-site rRNA cocrystal complexes of functionally novel aminoglycoside antibiotics: C2" ether analogues of paromomycinStephen Hanessian, Janek Szychowski, Susanta Sekhar Adhikari, et al.
ACS Chemical Biology|January 17, 2022
Quantitative Measurement of Cytosolic and Nuclear Penetration of Oligonucleotide TherapeuticsKirsten Deprey, Nefeli Batistatou, Marjoke F Debets, et al.
Translational Vision Science & Technology|January 29, 2021
Stereochemistry Enhances Potency, Efficacy, and Durability of <i>Malat1</i> Antisense Oligonucleotides In Vitro and In Vivo in Multiple SpeciesMichael Byrne, Vinod Vathipadiekal, Luciano Apponi, et al.
ACS Chemical Biology|March 3, 2015
siRNA conjugates carrying sequentially assembled trivalent N-acetylgalactosamine linked through nucleosides elicit robust gene silencing in vivo in hepatocytesShigeo Matsuda, Kristofer Keiser, Jayaprakash K Nair, et al.
Nature Communications|February 9, 2021
Variant-selective stereopure oligonucleotides protect against pathologies associated with C9orf72-repeat expansion in preclinical modelsYuanjing Liu, Jean-Cosme Dodart, Helene Tran, et al.
Journal of Medicinal Chemistry|February 9, 2023
Metabolically Stable Anomeric Linkages Containing GalNAc-siRNA Conjugates: An Interplay among ASGPR, Glycosidase, and RISC PathwaysPachamuthu Kandasamy, Shohei Mori, Shigeo Matsuda, et al.
Nucleic Acids Research|August 16, 2024
Rational design of base, sugar and backbone modifications improves ADAR-mediated RNA editingGenliang Lu, Chikdu Shivalila, Prashant Monian, et al.
Nucleic Acids Research|April 18, 2023
Impact of stereopure chimeric backbone chemistries on the potency and durability of gene silencing by RNA interferenceWei Liu, Naoki Iwamoto, Subramanian Marappan, et al.
Journal of the American Chemical Society|December 2, 2014
Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits robust RNAi-mediated gene silencingJayaprakash K Nair, Jennifer L S Willoughby, Amy Chan, et al.
Molecular Therapy : the Journal of the American Society of Gene Therapy|June 27, 2013
Biodegradable lipids enabling rapidly eliminated lipid nanoparticles for systemic delivery of RNAi therapeuticsMartin A Maier, Muthusamy Jayaraman, Shigeo Matsuda, et al.
Pageof 2