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Biomolecules|January 25, 2025
Functional Characterization of the SHIP1-Domains Regarding Their Contribution to Inositol 5-Phosphatase ActivitySpike Murphy Müller, Nina Nelson, Manfred Jücker
International Journal of Molecular Sciences|February 11, 2023
The Role of PI3K/AKT/mTOR Signaling in Hepatocellular Carcinoma MetabolismLing-Yu Tian, Daniel J Smit, Manfred Jücker
Oncogene|October 17, 2003
An increase in the expression and total activity of endogenous p60(c-Src) in several factor-independent mutants of a human GM-CSF-dependent leukemia cell line (TF-1)Stefan Horn, Johann Meyer, Carol Stocking, et al.
Leukemia & Lymphoma|November 17, 2010
Posttranscriptional regulation of the p85α adapter subunit of phosphatidylinositol 3-kinase in human leukemia cellsBianca T Hofmann, Elion Hoxha, Evita Mohr, et al.
Biochemical and Biophysical Research Communications|July 2, 2021
AKT1 and PTEN show the highest affinities among phosphoinositide binding proteins for the second messengers PtdIns(3,4,5)P3 and PtdIns(3,4)P2Nina Nelson, Adelia Razeto, Alessia Gilardi, et al.
Cellular Signalling|July 23, 2011
Distinct functional roles of Akt isoforms for proliferation, survival, migration and EGF-mediated signalling in lung cancer derived disseminated tumor cellsNicole Grabinski, Kai Bartkowiak, Katharina Grupp, et al.
Cellular Signalling|May 19, 2023
Targeted hyperactivation of AKT through inhibition of ectopic expressed SHIP1 induces cell death in colon carcinoma cells and derived metastasesPatrick A H Ehm, Michael Linnebacher, Andreas Block, et al.
GMS Zeitschrift Fur Medizinische Ausbildung|February 28, 2014
"Alcohol and nicotine"--Concept and evaluation of an interdisciplinary elective course with OSPE in preclinical medical educationCorinna Bergelt, Heidrun Lauke, Corinna Petersen-Ewert, et al.
Cellular Signalling|July 24, 2012
Leukemia-associated mutations in SHIP1 inhibit its enzymatic activity, interaction with the GM-CSF receptor and Grb2, and its ability to inactivate PI3K/AKT signalingHelena Brauer, Julia Strauss, Wiebke Wegner, et al.
Investigational New Drugs|August 26, 2014
Dual Inhibition of PI3K-AKT-mTOR- and RAF-MEK-ERK-signaling is synergistic in cholangiocarcinoma and reverses acquired resistance to MEK-inhibitorsFlorian Ewald, Dominik Nörz, Astrid Grottke, et al.
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