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Cell Discovery|July 28, 2016
An allosteric role for receptor activity-modifying proteins in defining GPCR pharmacologyJoseph J Gingell, John Simms, James Barwell, et al.
Plos Computational Biology|November 14, 2017
Improving virtual screening of G protein-coupled receptors via ligand-directed modelingThomas Coudrat, John Simms, Arthur Christopoulos, et al.
Peptides|March 16, 2011
Structure-function analysis of amino acid 74 of human RAMP1 and RAMP3 and its role in peptide interactions with adrenomedullin and calcitonin gene-related peptide receptorsTao Qi, Kien Ly, David R Poyner, et al.
Molecular Pharmacology|July 3, 2008
Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide, adrenomedullin, and amylin receptor functionTao Qi, George Christopoulos, Richard J Bailey, et al.
Proceedings of the National Academy of Sciences of the United States of America|March 13, 2013
Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformationsDenise Wootten, John Simms, Laurence J Miller, et al.
Maturitas|September 19, 2009
Calcitonin gene-related peptide, adrenomedullin and flushingDebbie L Hay, David R Poyner
British Journal of Pharmacology|April 12, 2012
Secretin family (Class B) G protein-coupled receptors - from molecular to clinical perspectivesDavid R Poyner, Debbie L Hay
Annals of the New York Academy of Sciences|August 5, 2006
Complexing receptor pharmacology: modulation of family B G protein-coupled receptor function by RAMPsPatrick M Sexton, Maria Morfis, Nanda Tilakaratne, et al.
The Journal of Pharmacology and Experimental Therapeutics|January 30, 2015
Differential impact of amino acid substitutions on critical residues of the human glucagon-like peptide-1 receptor involved in peptide activity and small-molecule allosteryCassandra Koole, Denise Wootten, John Simms, et al.
The Journal of Biological Chemistry|December 8, 2011
Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) has a critical role in GLP-1 peptide binding and receptor activationCassandra Koole, Denise Wootten, John Simms, et al.
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