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Journal of Pharmaceutical Sciences
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May 25, 2025
Which unbound fraction should we use in the well-stirred model for more accurately predicting hepatic clearance of drugs for humans?
Patrick Poulin
Journal of Pharmaceutical Sciences
|
April 25, 2013
Prediction of total hepatic clearance by combining metabolism, transport, and permeability data in the in vitro-in vivo extrapolation methods: emphasis on an apparent fraction unbound in liver for drugs
Patrick Poulin
Journal of Pharmaceutical Sciences
|
May 25, 2024
First-in-Human Predictions of Hepatic Clearance for Drugs With the Well-Stirred Model: Comparative Assessment Between Models of Fraction Unbound Based Either on the Free Drug Hypothesis, Albumin-Facilitated Hepatic Uptake or Dynamic Binding Kinetics
Patrick Poulin
Clinical Pharmacokinetics
|
September 8, 2011
A single-species approach considering additional physiological information for prediction of hepatic clearance of glycoprotein derivate therapeutics
Patrick Poulin
Journal of Pharmaceutical Sciences
|
May 7, 2015
A paradigm shift in pharmacokinetic-pharmacodynamic (PKPD) modeling: rule of thumb for estimating free drug level in tissue compared with plasma to guide drug design
Patrick Poulin
Journal of Pharmaceutical Sciences
|
September 12, 2024
An overview of interpretability of two models of unbound fraction that are used in combination with the well-stirred model for predicting hepatic clearance of drugs
Patrick Poulin
Journal of Pharmaceutical Sciences
|
March 27, 2015
Drug Distribution to Human Tissues: Prediction and Examination of the Basic Assumption in In Vivo Pharmacokinetics-Pharmacodynamics (PK/PD) Research
Patrick Poulin
Talanta
|
December 17, 2008
Determination of ammonium using a microplate-based fluorometric technique
Patrick Poulin, Emilien Pelletier
Journal of Pharmaceutical Sciences
|
May 15, 2013
Hepatocyte composition-based model as a mechanistic tool for predicting the cell suspension: aqueous phase partition coefficient of drugs in in vitro metabolic studies
Patrick Poulin, Sami Haddad
Regulatory Toxicology and Pharmacology : RTP
|
November 7, 2017
Integration of a plasma protein binding factor to the Chemical-Specific Adjustment Factor (CSAF) for facilitating the estimation of uncertainties in interspecies extrapolations when deriving health-based exposure limits for active pharmaceutical ingredients: Investigation of recent drug datasets
Patrick Poulin, Richard Arnett
Page
of 6
Search research articles
Search
Showing results (1-10 of 58) with videos related to
Sort By:
Page
of 6
Journal of Pharmaceutical Sciences
|
May 25, 2025
Which unbound fraction should we use in the well-stirred model for more accurately predicting hepatic clearance of drugs for humans?
Patrick Poulin
Journal of Pharmaceutical Sciences
|
April 25, 2013
Prediction of total hepatic clearance by combining metabolism, transport, and permeability data in the in vitro-in vivo extrapolation methods: emphasis on an apparent fraction unbound in liver for drugs
Patrick Poulin
Journal of Pharmaceutical Sciences
|
May 25, 2024
First-in-Human Predictions of Hepatic Clearance for Drugs With the Well-Stirred Model: Comparative Assessment Between Models of Fraction Unbound Based Either on the Free Drug Hypothesis, Albumin-Facilitated Hepatic Uptake or Dynamic Binding Kinetics
Patrick Poulin
Clinical Pharmacokinetics
|
September 8, 2011
A single-species approach considering additional physiological information for prediction of hepatic clearance of glycoprotein derivate therapeutics
Patrick Poulin
Journal of Pharmaceutical Sciences
|
May 7, 2015
A paradigm shift in pharmacokinetic-pharmacodynamic (PKPD) modeling: rule of thumb for estimating free drug level in tissue compared with plasma to guide drug design
Patrick Poulin
Journal of Pharmaceutical Sciences
|
September 12, 2024
An overview of interpretability of two models of unbound fraction that are used in combination with the well-stirred model for predicting hepatic clearance of drugs
Patrick Poulin
Journal of Pharmaceutical Sciences
|
March 27, 2015
Drug Distribution to Human Tissues: Prediction and Examination of the Basic Assumption in In Vivo Pharmacokinetics-Pharmacodynamics (PK/PD) Research
Patrick Poulin
Talanta
|
December 17, 2008
Determination of ammonium using a microplate-based fluorometric technique
Patrick Poulin, Emilien Pelletier
Journal of Pharmaceutical Sciences
|
May 15, 2013
Hepatocyte composition-based model as a mechanistic tool for predicting the cell suspension: aqueous phase partition coefficient of drugs in in vitro metabolic studies
Patrick Poulin, Sami Haddad
Regulatory Toxicology and Pharmacology : RTP
|
November 7, 2017
Integration of a plasma protein binding factor to the Chemical-Specific Adjustment Factor (CSAF) for facilitating the estimation of uncertainties in interspecies extrapolations when deriving health-based exposure limits for active pharmaceutical ingredients: Investigation of recent drug datasets
Patrick Poulin, Richard Arnett
Page
of 6