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Patrick Poulin

Showing results (11-20 of 58) with videos related to

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Journal of Pharmaceutical Sciences|October 13, 2015
Albumin and Uptake of Drugs in Cells: Additional Validation Exercises of a Recently Published Equation that Quantifies the Albumin-Facilitated Uptake Mechanism(s) in Physiologically Based Pharmacokinetic and Pharmacodynamic Modeling ResearchPatrick Poulin, Sami Haddad
Journal of Pharmaceutical Sciences|March 16, 2013
Toward a new paradigm for the efficient in vitro-in vivo extrapolation of metabolic clearance in humans from hepatocyte dataPatrick Poulin, Sami Haddad
Journal of Pharmaceutical Sciences|March 24, 2018
Extrapolation of the Hepatic Clearance of Drugs in the Absence of Albumin In Vitro to That in the Presence of Albumin In Vivo: Comparative Assessement of 2 Extrapolation Models Based on the Albumin-Mediated Hepatic Uptake Theory and Limitations and Mechanistic InsightsPatrick Poulin, Sami Haddad
Journal of Pharmaceutical Sciences|March 6, 2012
Advancing prediction of tissue distribution and volume of distribution of highly lipophilic compounds from a simplified tissue-composition-based model as a mechanistic animal alternative methodPatrick Poulin, Sami Haddad
Journal of Pharmaceutical Sciences|May 17, 2011
Microsome composition-based model as a mechanistic tool to predict nonspecific binding of drugs in liver microsomesPatrick Poulin, Sami Haddad
Journal of Pharmaceutical Sciences|April 15, 2021
A New Guidance for the Prediction of Hepatic Clearance in the Early Drug Discovery and Development from the in Vitro-to-in Vivo Extrapolation Method and an Approach for Exploring Whether an Albumin-Mediated Hepatic Uptake Phenomenon Could be Present Under in Vivo ConditionsPatrick Poulin, Sami Haddad
Journal of Pharmaceutical Sciences|April 27, 2002
Prediction of pharmacokinetics prior to in vivo studies. II. Generic physiologically based pharmacokinetic models of drug dispositionPatrick Poulin, Frank-Peter Theil
Journal of Pharmaceutical Sciences|January 10, 2002
Prediction of pharmacokinetics prior to in vivo studies. 1. Mechanism-based prediction of volume of distributionPatrick Poulin, Frank-Peter Theil
Journal of Pharmaceutical Sciences|May 21, 2009
Development of a novel method for predicting human volume of distribution at steady-state of basic drugs and comparative assessment with existing methodsPatrick Poulin, Frank-Peter Theil
Journal of Pharmaceutical Sciences|November 20, 2020
Comparative Assessment of Extrapolation Methods Based on the Conventional Free Drug Hypothesis and Plasma Protein-Mediated Hepatic Uptake Theory for the Hepatic Clearance Predictions of Two Drugs Extensively Bound to Both the Albumin And Alpha-1-Acid GlycoproteinMichel Bteich, Patrick Poulin, Sami Haddad
Pageof 6

Showing results (11-20 of 58) with videos related to

Sort By:
Pageof 6
Journal of Pharmaceutical Sciences|October 13, 2015
Albumin and Uptake of Drugs in Cells: Additional Validation Exercises of a Recently Published Equation that Quantifies the Albumin-Facilitated Uptake Mechanism(s) in Physiologically Based Pharmacokinetic and Pharmacodynamic Modeling ResearchPatrick Poulin, Sami Haddad
Journal of Pharmaceutical Sciences|March 16, 2013
Toward a new paradigm for the efficient in vitro-in vivo extrapolation of metabolic clearance in humans from hepatocyte dataPatrick Poulin, Sami Haddad
Journal of Pharmaceutical Sciences|March 24, 2018
Extrapolation of the Hepatic Clearance of Drugs in the Absence of Albumin In Vitro to That in the Presence of Albumin In Vivo: Comparative Assessement of 2 Extrapolation Models Based on the Albumin-Mediated Hepatic Uptake Theory and Limitations and Mechanistic InsightsPatrick Poulin, Sami Haddad
Journal of Pharmaceutical Sciences|March 6, 2012
Advancing prediction of tissue distribution and volume of distribution of highly lipophilic compounds from a simplified tissue-composition-based model as a mechanistic animal alternative methodPatrick Poulin, Sami Haddad
Journal of Pharmaceutical Sciences|May 17, 2011
Microsome composition-based model as a mechanistic tool to predict nonspecific binding of drugs in liver microsomesPatrick Poulin, Sami Haddad
Journal of Pharmaceutical Sciences|April 15, 2021
A New Guidance for the Prediction of Hepatic Clearance in the Early Drug Discovery and Development from the in Vitro-to-in Vivo Extrapolation Method and an Approach for Exploring Whether an Albumin-Mediated Hepatic Uptake Phenomenon Could be Present Under in Vivo ConditionsPatrick Poulin, Sami Haddad
Journal of Pharmaceutical Sciences|April 27, 2002
Prediction of pharmacokinetics prior to in vivo studies. II. Generic physiologically based pharmacokinetic models of drug dispositionPatrick Poulin, Frank-Peter Theil
Journal of Pharmaceutical Sciences|January 10, 2002
Prediction of pharmacokinetics prior to in vivo studies. 1. Mechanism-based prediction of volume of distributionPatrick Poulin, Frank-Peter Theil
Journal of Pharmaceutical Sciences|May 21, 2009
Development of a novel method for predicting human volume of distribution at steady-state of basic drugs and comparative assessment with existing methodsPatrick Poulin, Frank-Peter Theil
Journal of Pharmaceutical Sciences|November 20, 2020
Comparative Assessment of Extrapolation Methods Based on the Conventional Free Drug Hypothesis and Plasma Protein-Mediated Hepatic Uptake Theory for the Hepatic Clearance Predictions of Two Drugs Extensively Bound to Both the Albumin And Alpha-1-Acid GlycoproteinMichel Bteich, Patrick Poulin, Sami Haddad
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