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Patrick R Verhoest

Showing results (1-10 of 38) with videos related to

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Journal of Medicinal Chemistry|July 25, 2015
Challenges and Opportunities in the Discovery of New Therapeutics Targeting the Kynurenine PathwayAmy B Dounay, Jamison B Tuttle, Patrick R Verhoest
ACS Chemical Neuroscience|March 19, 2016
Central Nervous System Multiparameter Optimization Desirability: Application in Drug DiscoveryTravis T Wager, Xinjun Hou, Patrick R Verhoest, et al.
ACS Chemical Neuroscience|July 11, 2012
Moving beyond rules: the development of a central nervous system multiparameter optimization (CNS MPO) approach to enable alignment of druglike propertiesTravis T Wager, Xinjun Hou, Patrick R Verhoest, et al.
Expert Opinion on Drug Discovery|June 1, 2012
Strategies to optimize the brain availability of central nervous system drug candidatesTravis T Wager, Anabella Villalobos, Patrick R Verhoest, et al.
Journal of Medicinal Chemistry|July 27, 2013
Evaluating the differences in cycloalkyl ether metabolism using the design parameter "lipophilic metabolism efficiency" (LipMetE) and a matched molecular pairs analysisAntonia F Stepan, Gregory W Kauffman, Christopher E Keefer, et al.
Journal of Medicinal Chemistry|May 27, 2016
Quantitative Assessment of the Impact of Fluorine Substitution on P-Glycoprotein (P-gp) Mediated Efflux, Permeability, Lipophilicity, and Metabolic StabilityMartin Pettersson, Xinjun Hou, Max Kuhn, et al.
ACS Chemical Neuroscience|July 11, 2012
Defining desirable central nervous system drug space through the alignment of molecular properties, in vitro ADME, and safety attributesTravis T Wager, Ramalakshmi Y Chandrasekaran, Xinjun Hou, et al.
The Journal of Pharmacology and Experimental Therapeutics|December 10, 2015
Identification of Phosphorylation Consensus Sequences and Endogenous Neuronal Substrates of the Psychiatric Risk Kinase TNIKQi Wang, Stephen P Amato, David M Rubitski, et al.
ACS Chemical Biology|October 9, 2014
Chemoproteomics demonstrates target engagement and exquisite selectivity of the clinical phosphodiesterase 10A inhibitor MP-10 in its native environmentJan-Philip Schülke, Laura A McAllister, Kieran F Geoghegan, et al.
The Journal of Organic Chemistry|April 2, 2011
A general strategy for the synthesis of cyclic N-aryl hydroxamic acids via partial nitro group reductionLaura A McAllister, Bruce M Bechle, Amy B Dounay, et al.
Pageof 4

Showing results (1-10 of 38) with videos related to

Sort By:
Pageof 4
Journal of Medicinal Chemistry|July 25, 2015
Challenges and Opportunities in the Discovery of New Therapeutics Targeting the Kynurenine PathwayAmy B Dounay, Jamison B Tuttle, Patrick R Verhoest
ACS Chemical Neuroscience|March 19, 2016
Central Nervous System Multiparameter Optimization Desirability: Application in Drug DiscoveryTravis T Wager, Xinjun Hou, Patrick R Verhoest, et al.
ACS Chemical Neuroscience|July 11, 2012
Moving beyond rules: the development of a central nervous system multiparameter optimization (CNS MPO) approach to enable alignment of druglike propertiesTravis T Wager, Xinjun Hou, Patrick R Verhoest, et al.
Expert Opinion on Drug Discovery|June 1, 2012
Strategies to optimize the brain availability of central nervous system drug candidatesTravis T Wager, Anabella Villalobos, Patrick R Verhoest, et al.
Journal of Medicinal Chemistry|July 27, 2013
Evaluating the differences in cycloalkyl ether metabolism using the design parameter "lipophilic metabolism efficiency" (LipMetE) and a matched molecular pairs analysisAntonia F Stepan, Gregory W Kauffman, Christopher E Keefer, et al.
Journal of Medicinal Chemistry|May 27, 2016
Quantitative Assessment of the Impact of Fluorine Substitution on P-Glycoprotein (P-gp) Mediated Efflux, Permeability, Lipophilicity, and Metabolic StabilityMartin Pettersson, Xinjun Hou, Max Kuhn, et al.
ACS Chemical Neuroscience|July 11, 2012
Defining desirable central nervous system drug space through the alignment of molecular properties, in vitro ADME, and safety attributesTravis T Wager, Ramalakshmi Y Chandrasekaran, Xinjun Hou, et al.
The Journal of Pharmacology and Experimental Therapeutics|December 10, 2015
Identification of Phosphorylation Consensus Sequences and Endogenous Neuronal Substrates of the Psychiatric Risk Kinase TNIKQi Wang, Stephen P Amato, David M Rubitski, et al.
ACS Chemical Biology|October 9, 2014
Chemoproteomics demonstrates target engagement and exquisite selectivity of the clinical phosphodiesterase 10A inhibitor MP-10 in its native environmentJan-Philip Schülke, Laura A McAllister, Kieran F Geoghegan, et al.
The Journal of Organic Chemistry|April 2, 2011
A general strategy for the synthesis of cyclic N-aryl hydroxamic acids via partial nitro group reductionLaura A McAllister, Bruce M Bechle, Amy B Dounay, et al.
Pageof 4