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Expert Opinion on Drug Metabolism & Toxicology
|
March 31, 2012
Strategies to minimize CNS toxicity: in vitro high-throughput assays and computational modeling
Travis T Wager, Jennifer L Liras, Scot Mente, et al.
Pharmacology Research & Perspectives
|
March 4, 2021
Optimization of dose and route of administration of the P-glycoprotein inhibitor, valspodar (PSC-833) and the P-glycoprotein and breast cancer resistance protein dual-inhibitor, elacridar (GF120918) as dual infusion in rats
Christopher Rowbottom, Alicia Pietrasiewicz, Taras Tuczewycz, et al.
Journal of Chemical Information and Modeling
|
May 22, 2023
Prospective Validation of Machine Learning Algorithms for Absorption, Distribution, Metabolism, and Excretion Prediction: An Industrial Perspective
Cheng Fang, Ye Wang, Richard Grater, et al.
Molecular Therapy. Methods & Clinical Development
|
September 30, 2021
Development of a one-step RT-ddPCR method to determine the expression and potency of AAV vectors
Pete Clarner, Shukkwan K Lau, Twinkle Chowdhury, et al.
ACS Chemical Neuroscience
|
January 24, 2020
D1 Agonist Improved Movement of Parkinsonian Nonhuman Primates with Limited Dyskinesia Side Effects
Damon Young, Michael Popiolek, Patrick Trapa, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals
|
May 31, 2012
A novel relay method for determining low-clearance values
Li Di, Patrick Trapa, R Scott Obach, et al.
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
|
May 15, 2025
A novel approach for modeling <i>in vivo</i> enzyme turnover in the presence of a suicide inhibitor drug: A proof-of-concept brain PET study on MAG lipase
Tommaso Volpi, Daniel Holden, Jean-Dominique Gallezot, et al.
Journal of Medicinal Chemistry
|
March 12, 2024
The Discovery of 7-Isopropoxy-2-(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)-<i>N</i>-(6-methylpyrazolo[1,5-<i>a</i>]pyrimidin-3-yl)imidazo[1,2-<i>a</i>]pyrimidine-6-carboxamide (BIO-7488), a Potent, Selective, and CNS-Penetrant IRAK4 Inhibitor for the Treatment of Ischemic Stroke
Ryan Evans, Philippe N Bolduc, Magnus Pfaffenbach, et al.
Journal of Medicinal Chemistry
|
September 5, 2019
Identification and Development of an Irreversible Monoacylglycerol Lipase (MAGL) Positron Emission Tomography (PET) Radioligand with High Specificity
Lei Zhang, Christopher R Butler, Kevin P Maresca, et al.
Drug Discovery Today
|
May 7, 2017
Translational pharmacokinetic-pharmacodynamic analysis in the pharmaceutical industry: an IQ Consortium PK-PD Discussion Group perspective
Harvey Wong, Tonika Bohnert, Valeriu Damian-Iordache, et al.
Page
of 2
Search research articles
Search
Showing results (1-10 of 20) with videos related to
Sort By:
Page
of 2
Expert Opinion on Drug Metabolism & Toxicology
|
March 31, 2012
Strategies to minimize CNS toxicity: in vitro high-throughput assays and computational modeling
Travis T Wager, Jennifer L Liras, Scot Mente, et al.
Pharmacology Research & Perspectives
|
March 4, 2021
Optimization of dose and route of administration of the P-glycoprotein inhibitor, valspodar (PSC-833) and the P-glycoprotein and breast cancer resistance protein dual-inhibitor, elacridar (GF120918) as dual infusion in rats
Christopher Rowbottom, Alicia Pietrasiewicz, Taras Tuczewycz, et al.
Journal of Chemical Information and Modeling
|
May 22, 2023
Prospective Validation of Machine Learning Algorithms for Absorption, Distribution, Metabolism, and Excretion Prediction: An Industrial Perspective
Cheng Fang, Ye Wang, Richard Grater, et al.
Molecular Therapy. Methods & Clinical Development
|
September 30, 2021
Development of a one-step RT-ddPCR method to determine the expression and potency of AAV vectors
Pete Clarner, Shukkwan K Lau, Twinkle Chowdhury, et al.
ACS Chemical Neuroscience
|
January 24, 2020
D1 Agonist Improved Movement of Parkinsonian Nonhuman Primates with Limited Dyskinesia Side Effects
Damon Young, Michael Popiolek, Patrick Trapa, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals
|
May 31, 2012
A novel relay method for determining low-clearance values
Li Di, Patrick Trapa, R Scott Obach, et al.
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
|
May 15, 2025
A novel approach for modeling <i>in vivo</i> enzyme turnover in the presence of a suicide inhibitor drug: A proof-of-concept brain PET study on MAG lipase
Tommaso Volpi, Daniel Holden, Jean-Dominique Gallezot, et al.
Journal of Medicinal Chemistry
|
March 12, 2024
The Discovery of 7-Isopropoxy-2-(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)-<i>N</i>-(6-methylpyrazolo[1,5-<i>a</i>]pyrimidin-3-yl)imidazo[1,2-<i>a</i>]pyrimidine-6-carboxamide (BIO-7488), a Potent, Selective, and CNS-Penetrant IRAK4 Inhibitor for the Treatment of Ischemic Stroke
Ryan Evans, Philippe N Bolduc, Magnus Pfaffenbach, et al.
Journal of Medicinal Chemistry
|
September 5, 2019
Identification and Development of an Irreversible Monoacylglycerol Lipase (MAGL) Positron Emission Tomography (PET) Radioligand with High Specificity
Lei Zhang, Christopher R Butler, Kevin P Maresca, et al.
Drug Discovery Today
|
May 7, 2017
Translational pharmacokinetic-pharmacodynamic analysis in the pharmaceutical industry: an IQ Consortium PK-PD Discussion Group perspective
Harvey Wong, Tonika Bohnert, Valeriu Damian-Iordache, et al.
Page
of 2