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EJNMMI Research
|
March 4, 2022
Target occupancy study and whole-body dosimetry with a MAGL PET ligand [<sup>11</sup>C]PF-06809247 in non-human primates
Ryosuke Arakawa, Akihiro Takano, Sangram Nag, et al.
Toxicologic Pathology
|
February 22, 2024
Adeno-Associated Virus-Mediated Dorsal Root Ganglion Toxicity in the New Zealand White Rabbit
Eric Tien, Branka Grubor, Melissa Kirkland, et al.
The AAPS Journal
|
January 30, 2015
Preclinical pharmacokinetic/pharmacodynamic modeling and simulation in the pharmaceutical industry: an IQ consortium survey examining the current landscape
Edgar Schuck, Tonika Bohnert, Arijit Chakravarty, et al.
Molecular Therapy : the Journal of the American Society of Gene Therapy
|
November 20, 2024
Dorsal root ganglion toxicity after AAV intra-CSF delivery of a RNAi expression construct into non-human primates and mice
Zachary C E Hawley, Ingrid D Pardo, Shaolong Cao, et al.
Clinical & Translational Immunology
|
June 18, 2021
Next-generation Bruton's tyrosine kinase inhibitor BIIB091 selectively and potently inhibits B cell and Fc receptor signaling and downstream functions in B cells and myeloid cells
Eris Bame, Hao Tang, Jeremy C Burns, et al.
Journal of Medicinal Chemistry
|
January 8, 2014
Discovery and preclinical characterization of 1-methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)-1H-pyrazolo-[3,4-b]pyrazine (PF470): a highly potent, selective, and efficacious metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator
Lei Zhang, Gayatri Balan, Gabriela Barreiro, et al.
Journal of Medicinal Chemistry
|
June 7, 2024
Discovery of Clinical Candidate PF-06648671: A Potent γ-Secretase Modulator for the Treatment of Alzheimer's Disease
Martin Pettersson, Douglas S Johnson, John M Humphrey, et al.
Angewandte Chemie (International Ed. in English)
|
June 30, 2016
Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging
Steven H Liang, Jinshan Michael Chen, Marc D Normandin, et al.
Journal of Medicinal Chemistry
|
August 18, 2017
Discovery and Characterization of (R)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates
Antonia F Stepan, Michelle M Claffey, Matthew R Reese, et al.
Molecular Therapy. Methods & Clinical Development
|
December 17, 2025
Inhibition of immune response reduces pathology in dorsal root ganglia and peripheral nerves in cynomolgus macaques following AAV gene therapy
Branka Grubor, Kate L Henry, Su Jing Chan, et al.
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Search research articles
Search
Showing results (11-20 of 20) with videos related to
Sort By:
Page
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You have reached the last page of results.
This site can display upto 20 results.
EJNMMI Research
|
March 4, 2022
Target occupancy study and whole-body dosimetry with a MAGL PET ligand [<sup>11</sup>C]PF-06809247 in non-human primates
Ryosuke Arakawa, Akihiro Takano, Sangram Nag, et al.
Toxicologic Pathology
|
February 22, 2024
Adeno-Associated Virus-Mediated Dorsal Root Ganglion Toxicity in the New Zealand White Rabbit
Eric Tien, Branka Grubor, Melissa Kirkland, et al.
The AAPS Journal
|
January 30, 2015
Preclinical pharmacokinetic/pharmacodynamic modeling and simulation in the pharmaceutical industry: an IQ consortium survey examining the current landscape
Edgar Schuck, Tonika Bohnert, Arijit Chakravarty, et al.
Molecular Therapy : the Journal of the American Society of Gene Therapy
|
November 20, 2024
Dorsal root ganglion toxicity after AAV intra-CSF delivery of a RNAi expression construct into non-human primates and mice
Zachary C E Hawley, Ingrid D Pardo, Shaolong Cao, et al.
Clinical & Translational Immunology
|
June 18, 2021
Next-generation Bruton's tyrosine kinase inhibitor BIIB091 selectively and potently inhibits B cell and Fc receptor signaling and downstream functions in B cells and myeloid cells
Eris Bame, Hao Tang, Jeremy C Burns, et al.
Journal of Medicinal Chemistry
|
January 8, 2014
Discovery and preclinical characterization of 1-methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)-1H-pyrazolo-[3,4-b]pyrazine (PF470): a highly potent, selective, and efficacious metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator
Lei Zhang, Gayatri Balan, Gabriela Barreiro, et al.
Journal of Medicinal Chemistry
|
June 7, 2024
Discovery of Clinical Candidate PF-06648671: A Potent γ-Secretase Modulator for the Treatment of Alzheimer's Disease
Martin Pettersson, Douglas S Johnson, John M Humphrey, et al.
Angewandte Chemie (International Ed. in English)
|
June 30, 2016
Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging
Steven H Liang, Jinshan Michael Chen, Marc D Normandin, et al.
Journal of Medicinal Chemistry
|
August 18, 2017
Discovery and Characterization of (R)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates
Antonia F Stepan, Michelle M Claffey, Matthew R Reese, et al.
Molecular Therapy. Methods & Clinical Development
|
December 17, 2025
Inhibition of immune response reduces pathology in dorsal root ganglia and peripheral nerves in cynomolgus macaques following AAV gene therapy
Branka Grubor, Kate L Henry, Su Jing Chan, et al.
Page
of 2