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The Journal of Clinical Investigation|February 7, 2017
The chromatin remodeling factor CHD7 controls cerebellar development by regulating reelin expressionDanielle E Whittaker, Kimberley L H Riegman, Sahrunizam Kasah, et al.
Cell Stem Cell|August 30, 2016
MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control HematopoiesisBeatriz Aranda-Orgilles, Ricardo Saldaña-Meyer, Eric Wang, et al.
Cell|August 13, 2017
An Engineered orco Mutation Produces Aberrant Social Behavior and Defective Neural Development in AntsHua Yan, Comzit Opachaloemphan, Giacomo Mancini, et al.
Nucleic Acids Research|June 13, 2023
SIRT1 regulates DNA damage signaling through the PP4 phosphatase complexGeorge Rasti, Maximilian Becker, Berta N Vazquez, et al.
Bioorganic & Medicinal Chemistry Letters|May 18, 2017
From a novel HTS hit to potent, selective, and orally bioavailable KDM5 inhibitorsJun Liang, Sharada Labadie, Birong Zhang, et al.
Cancer Research|June 4, 2024
Comprehensive Target Engagement by the EZH2 Inhibitor Tulmimetostat Allows for Targeting of ARID1A Mutant CancersPatricia J Keller, Elizabeth J Adams, Rentian Wu, et al.
Journal of Medicinal Chemistry|October 15, 2016
Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell LymphomasRishi G Vaswani, Victor S Gehling, Les A Dakin, et al.
Molecular Cell|October 12, 2021
NRF1 association with AUTS2-Polycomb mediates specific gene activation in the brainSanxiong Liu, Kimberly A Aldinger, Chi Vicky Cheng, et al.
Chemistry & Biology|December 3, 2014
EZH2 inhibitor efficacy in non-Hodgkin's lymphoma does not require suppression of H3K27 monomethylationWilliam D Bradley, Shilpi Arora, Jennifer Busby, et al.
Cell Reports|November 2, 2017
Low-Grade Astrocytoma Mutations in IDH1, P53, and ATRX Cooperate to Block Differentiation of Human Neural Stem Cells via Repression of SOX2Aram S Modrek, Danielle Golub, Themasap Khan, et al.
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