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Cancer Research|December 11, 2025
The Histone Methyltransferase KMT2D is a Critical Mediator of Lineage Plasticity and Therapeutic Response in Castration Resistant Prostate CancerSrushti Kittane, Erik Ladewig, Taibo Li, et al.Elife|April 25, 2022
Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologsAntonio Cuevas-Navarro, Laura Rodriguez-Muñoz, Joaquim Grego-Bessa, et al.Cancer Discovery|September 9, 2016
Systematic Functional Characterization of Resistance to PI3K Inhibition in Breast CancerXiuning Le, Rajee Antony, Pedram Razavi, et al.The EMBO Journal|August 3, 2016
The hVps34-SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growthRuzica Bago, Eeva Sommer, Pau Castel, et al.The Journal of Biological Chemistry|May 6, 2023
The ribosomal S6 kinase 2 (RSK2)-SPRED2 complex regulates the phosphorylation of RSK substrates and MAPK signalingJocelyne Lopez, Daniel A Bonsor, Matthew J Sale, et al.Cell Reports|April 13, 2025
TFE3 fusion oncoprotein condensates drive transcriptional reprogramming and cancer progression in translocation renal cell carcinomaChoon Leng So, Ye Jin Lee, Bujamin H Vokshi, et al.Science (New York, N.Y.)|March 16, 2019
RIT1 oncoproteins escape LZTR1-mediated proteolysisPau Castel, Alice Cheng, Antonio Cuevas-Navarro, et al.Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|May 27, 2016
Therapeutic Benefit of Selective Inhibition of p110α PI3-Kinase in Pancreatic Neuroendocrine TumorsAdriana Soler, Ana M Figueiredo, Pau Castel, et al.Iscience|August 20, 2024
The deubiquitinase USP9X regulates RIT1 protein abundance and oncogenic phenotypesAmanda K Riley, Michael Grant, Aidan Snell, et al.Science Translational Medicine|April 1, 2016
Somatic PIK3CA mutations as a driver of sporadic venous malformationsPau Castel, F Javier Carmona, Joaquim Grego-Bessa, et al.Pageof 9