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The Journal of Pharmacology and Experimental Therapeutics|May 2, 2003
Threonine-205 in the F helix of p450 2B1 contributes to androgen 16 beta-hydroxylation activity and mechanism-based inactivationHsia-Lien Lin, Haoming Zhang, Lucy Waskell, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|May 23, 2002
The licorice root derived isoflavan glabridin inhibits the activities of human cytochrome P450S 3A4, 2B6, and 2C9Ute M Kent, Michael Aviram, Mira Rosenblat, et al.
Chemical Research in Toxicology|August 30, 2008
Modification of serine 360 by a reactive intermediate of 17-alpha-ethynylestradiol results in mechanism-based inactivation of cytochrome P450s 2B1 and 2B6Ute M Kent, Chitra Sridar, Greg Spahlinger, et al.
Chemical Research in Toxicology|September 29, 2012
Reaction of human cytochrome P450 3A4 with peroxynitrite: nitrotyrosine formation on the proximal side impairs its interaction with NADPH-cytochrome P450 reductaseHsia-lien Lin, Cesar Kenaan, Haoming Zhang, et al.
Archives of Biochemistry and Biophysics|September 15, 2010
Targeting of the highly conserved threonine 302 residue of cytochromes P450 2B family during mechanism-based inactivation by aryl acetylenesHaoming Zhang, Hsia-lien Lin, Cesar Kenaan, et al.
Chemical Research in Toxicology|August 16, 2005
The highly conserved Glu149 and Tyr190 residues contribute to peroxynitrite-mediated nitrotyrosine formation and the catalytic activity of cytochrome P450 2B1Hsia-lien Lin, Haoming Zhang, Lucy Waskell, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|February 2, 2013
The inactivation of human CYP2E1 by phenethyl isothiocyanate, a naturally occurring chemopreventive agent, and its oxidative bioactivationYasushi Yoshigae, Chitra Sridar, Ute M Kent, et al.
Carcinogenesis|December 21, 2005
Effects of benzyl and phenethyl isothiocyanate on P450s 2A6 and 2A13: potential for chemoprevention in smokersLinda B von Weymarn, Jamie A Chun, Paul F Hollenberg
The Journal of Pharmacology and Experimental Therapeutics|March 5, 2010
Covalent modification of Thr302 in cytochrome P450 2B1 by the mechanism-based inactivator 4-tert-butylphenylacetyleneHsia-lien Lin, Haoming Zhang, Monica Jushchyshyn, et al.
Archives of Biochemistry and Biophysics|April 15, 2004
The mechanism-based inactivation of p450 2B4 by tert-butyl 1-methyl-2-propynyl ether: structural determination of the adducts to the p450 hemeLinda B von Weymarn, Anna L Blobaum, Paul F Hollenberg
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