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Molecular and Cellular Biology|June 25, 2014
Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein response, and disturbance in the expression of metabolic enzymes but not with insulin resistancePaul J Meakin, Sudhir Chowdhry, Ritu S Sharma, et al.
Redox Biology|October 9, 2021
Non-canonical Keap1-independent activation of Nrf2 in astrocytes by mild oxidative stressBashayer R Al-Mubarak, Karen F S Bell, Sudhir Chowdhry, et al.
Journal of Autoimmunity|May 16, 2015
Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasomeJustyna Rzepecka, Miguel A Pineda, Lamyaa Al-Riyami, et al.
The Biochemical Journal|September 2, 2011
Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in micePaul J Meakin, Alex J Harper, D Lee Hamilton, et al.
Scientific Reports|August 9, 2016
Dimethyl fumarate blocks pro-inflammatory cytokine production via inhibition of TLR induced M1 and K63 ubiquitin chain formationVictoria A McGuire, Tamara Ruiz-Zorrilla Diez, Christoph H Emmerich, et al.
Cardiovascular Research|August 24, 2024
The diabetic myocardial transcriptome reveals Erbb3 and Hspa2 as a novel biomarkers of incident heart failureMarcella S Conning-Rowland, Marilena Giannoudi, Michael Drozd, et al.
Metabolism: Clinical and Experimental|March 13, 2018
The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signalingGaia Botteri, Laia Salvadó, Anna Gumà, et al.
Antioxidants & Redox Signaling|November 14, 2013
Phosphoinositide 3-kinases upregulate system xc(-) via eukaryotic initiation factor 2α and activating transcription factor 4 - A pathway active in glioblastomas and epilepsyJan Lewerenz, Paul Baxter, Rebecca Kassubek, et al.
Arthritis Research & Therapy|September 2, 2025
Transforming growth factor beta (TGF-β) induces type 1 interferon signalling in systemic sclerosis keratinocytes through the chloride intracellular channel 4 (CLIC4)Christopher W Wasson, Sophie L Dibb, Begoña Caballero-Ruiz, et al.
The Journal of Clinical Investigation|May 15, 2020
Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunctionPaul J Meakin, Bethany M Coull, Zofia Tuharska, et al.
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