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Biorxiv : the Preprint Server for Biology|June 4, 2026
Transmembrane Domain Dominance Drives Emergent Signaling and Allosteric Inversion in mGlu 1/5 HeterodimersJustin B Steinfeld, Xia Lei, Madeline Laramee, et al.ACS Medicinal Chemistry Letters|July 14, 2026
Optimization of Pyrazole-Based Activators of Kv3.1Paul K Spearing, Vaishali Satpute Janke, Ian M Romaine, et al.Bioorganic & Medicinal Chemistry Letters|September 17, 2017
Identification of potent, nonabsorbable agonists of the calcium-sensing receptor for GI-specific administrationSteven M Sparks, Paul K Spearing, Caroline J Diaz, et al.Bioorganic & Medicinal Chemistry Letters|June 12, 2021
Discovery of a novel class of heteroaryl-pyrrolidinones as positive allosteric modulators of the muscarinic acetylcholine receptor M1Paul K Spearing, Hyekyung P Cho, Vincent B Luscombe, et al.Bioorganic & Medicinal Chemistry Letters|September 5, 2020
Synthesis and SAR of a series of mGlu7 NAMs based on an ethyl-8-methoxy-4-(4-phenylpiperazin-1-yl)quinoline carboxylate coreJacob J Kalbfleisch, Carson W Reed, Charlotte Park, et al.Bioorganic & Medicinal Chemistry Letters|September 4, 2017
Discovery of a novel, CNS penetrant M4 PAM chemotype based on a 6-fluoro-4-(piperidin-1-yl)quinoline-3-carbonitrile coreBlake R Bewley, Paul K Spearing, Rebecca L Weiner, et al.Bioorganic & Medicinal Chemistry Letters|September 6, 2011
Conformationally constrained farnesoid X receptor (FXR) agonists: alternative replacements of the stilbeneAdwoa Akwabi-Ameyaw, Justin A Caravella, Lihong Chen, et al.Journal of Medicinal Chemistry|March 30, 2010
Discovery of tertiary sulfonamides as potent liver X receptor antagonistsWilliam J Zuercher, Richard G Buckholz, Nino Campobasso, et al.Bioorganic & Medicinal Chemistry Letters|October 28, 2021
Discovery of structurally distinct tricyclic M4 positive allosteric modulator (PAM) chemotypes - Part 2Madeline F Long, Rory A Capstick, Paul K Spearing, et al.Bioorganic & Medicinal Chemistry Letters|January 25, 2011
Conformationally constrained farnesoid X receptor (FXR) agonists: heteroaryl replacements of the naphthaleneJonathan Y Bass, Justin A Caravella, Lihong Chen, et al.Pageof 2