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Chemical Science|November 25, 2024
Discovery of penicillic acid as a chemical probe against tau aggregation in Alzheimer's diseaseJennifer Shyong, Jinliang Wang, Quoc-Dung Tran Huynh, et al.
Chemical Science|July 2, 2026
Correction: Discovery of penicillic acid as a chemical probe against tau aggregation in Alzheimer's diseaseJennifer Shyong, Jinliang Wang, Quoc-Dung Tran Huynh, et al.
Nature Structural & Molecular Biology|May 31, 2022
Identifying amyloid-related diseases by mapping mutations in low-complexity protein domains to pathologiesKevin A Murray, Michael P Hughes, Carolyn J Hu, et al.
Proceedings of the National Academy of Sciences of the United States of America|August 15, 2022
De novo designed protein inhibitors of amyloid aggregation and seedingKevin A Murray, Carolyn J Hu, Sarah L Griner, et al.
Nature Chemical Biology|September 3, 2013
Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2Pallav D Patel, Pengrong Yan, Paul M Seidler, et al.
Chemical Science|October 20, 2023
A heterologous expression platform in Aspergillus nidulans for the elucidation of cryptic secondary metabolism biosynthetic gene clusters: discovery of the Aspergillus fumigatus sartorypyrone biosynthetic pathwayShu-Yi Lin, C Elizabeth Oakley, Cory B Jenkinson, et al.
Science Advances|January 31, 2025
Monoaminergic neurotransmitters are bimodal effectors of tau aggregationXinmin Chang, Amanda M Tse, Marina Fayzullina, et al.
Proceedings of the National Academy of Sciences of the United States of America|February 9, 2023
Small molecules disaggregate alpha-synuclein and prevent seeding from patient brain-derived fibrilsKevin A Murray, Carolyn J Hu, Hope Pan, et al.
Nature Communications|September 16, 2022
Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitroPaul M Seidler, Kevin A Murray, David R Boyer, et al.
The Journal of Biological Chemistry|June 5, 2020
Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's diseaseRomany Abskharon, Paul M Seidler, Michael R Sawaya, et al.
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