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Journal of Medicinal Chemistry
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January 10, 2017
Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies
Niall Igoe, Elliott D Bayle, Oleg Fedorov, et al.
Journal of Medicinal Chemistry
|
October 30, 2020
5-Phenyl-1,3,4-oxadiazol-2(3<i>H</i>)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit
William Mahy, Nicky J Willis, Yuguang Zhao, et al.
Biorxiv : the Preprint Server for Biology
|
February 23, 2021
Probing the SAM Binding Site of SARS-CoV-2 nsp14 in vitro Using SAM Competitive Inhibitors Guides Developing Selective bi-substrate Inhibitors
Kanchan Devkota, Matthieu Schapira, Sumera Perveen, et al.
SLAS Discovery : Advancing Life Sciences R & D
|
July 1, 2021
Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors
Kanchan Devkota, Matthieu Schapira, Sumera Perveen, et al.
Journal of Medicinal Chemistry
|
October 26, 2012
Identification of a chemical probe for bromo and extra C-terminal bromodomain inhibition through optimization of a fragment-derived hit
Paul V Fish, Panagis Filippakopoulos, Gerwyn Bish, et al.
Journal of Medicinal Chemistry
|
August 14, 2020
Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity
William Mahy, Mikesh Patel, David Steadman, et al.
ACS Chemical Neuroscience
|
June 22, 2022
Structural Analysis and Development of Notum Fragment Screening Hits
Yuguang Zhao, William Mahy, Nicky J Willis, et al.
Journal of Medicinal Chemistry
|
May 10, 2022
Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit
Nicky J Willis, William Mahy, James Sipthorp, et al.
Journal of Medicinal Chemistry
|
June 1, 2014
Multiparameter optimization in CNS drug discovery: design of pyrimido[4,5-d]azepines as potent 5-hydroxytryptamine 2C (5-HT₂C) receptor agonists with exquisite functional selectivity over 5-HT₂A and 5-HT₂B receptors
R Ian Storer, Paul E Brennan, Alan D Brown, et al.
Journal of Medicinal Chemistry
|
October 26, 2020
Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and <i>In Vivo</i> Efficacy in the <i>Plasmodium falciparum</i> NSG Mouse Model
André Horatscheck, Ana Andrijevic, Aloysius T Nchinda, et al.
Page
of 6
Search research articles
Search
Showing results (41-50 of 57) with videos related to
Sort By:
Page
of 6
Journal of Medicinal Chemistry
|
January 10, 2017
Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies
Niall Igoe, Elliott D Bayle, Oleg Fedorov, et al.
Journal of Medicinal Chemistry
|
October 30, 2020
5-Phenyl-1,3,4-oxadiazol-2(3<i>H</i>)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit
William Mahy, Nicky J Willis, Yuguang Zhao, et al.
Biorxiv : the Preprint Server for Biology
|
February 23, 2021
Probing the SAM Binding Site of SARS-CoV-2 nsp14 in vitro Using SAM Competitive Inhibitors Guides Developing Selective bi-substrate Inhibitors
Kanchan Devkota, Matthieu Schapira, Sumera Perveen, et al.
SLAS Discovery : Advancing Life Sciences R & D
|
July 1, 2021
Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors
Kanchan Devkota, Matthieu Schapira, Sumera Perveen, et al.
Journal of Medicinal Chemistry
|
October 26, 2012
Identification of a chemical probe for bromo and extra C-terminal bromodomain inhibition through optimization of a fragment-derived hit
Paul V Fish, Panagis Filippakopoulos, Gerwyn Bish, et al.
Journal of Medicinal Chemistry
|
August 14, 2020
Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity
William Mahy, Mikesh Patel, David Steadman, et al.
ACS Chemical Neuroscience
|
June 22, 2022
Structural Analysis and Development of Notum Fragment Screening Hits
Yuguang Zhao, William Mahy, Nicky J Willis, et al.
Journal of Medicinal Chemistry
|
May 10, 2022
Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit
Nicky J Willis, William Mahy, James Sipthorp, et al.
Journal of Medicinal Chemistry
|
June 1, 2014
Multiparameter optimization in CNS drug discovery: design of pyrimido[4,5-d]azepines as potent 5-hydroxytryptamine 2C (5-HT₂C) receptor agonists with exquisite functional selectivity over 5-HT₂A and 5-HT₂B receptors
R Ian Storer, Paul E Brennan, Alan D Brown, et al.
Journal of Medicinal Chemistry
|
October 26, 2020
Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and <i>In Vivo</i> Efficacy in the <i>Plasmodium falciparum</i> NSG Mouse Model
André Horatscheck, Ana Andrijevic, Aloysius T Nchinda, et al.
Page
of 6