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Nature Chemical Biology|March 19, 2013
ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 systemSigrun Polier, Rahul S Samant, Paul A Clarke, et al.
Nature Reviews. Drug Discovery|January 1, 2013
Objective assessment of cancer genes for drug discoveryMishal N Patel, Mark D Halling-Brown, Joseph E Tym, et al.
Scientific Reports|February 19, 2020
The kinase polypharmacology landscape of clinical PARP inhibitorsAlbert A Antolin, Malaka Ameratunga, Udai Banerji, et al.
American Journal of Medical Genetics. Part A|December 21, 2018
Burkitt lymphoma in a patient with Kabuki syndrome carrying a novel KMT2D mutationEmmanuel de Billy, Luisa Strocchio, Antonella Cacchione, et al.
Medchemcomm|October 18, 2016
Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9Carl S Rye, Nicola E A Chessum, Scott Lamont, et al.
Journal of Medicinal Chemistry|April 5, 2023
HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other MalignanciesA Elisa Pasqua, Swee Y Sharp, Nicola E A Chessum, et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|October 6, 2005
Pharmacokinetic-pharmacodynamic relationships for the heat shock protein 90 molecular chaperone inhibitor 17-allylamino, 17-demethoxygeldanamycin in human ovarian cancer xenograft modelsUdai Banerji, Michael Walton, Florence Raynaud, et al.
Bioorganic & Medicinal Chemistry|December 23, 2008
Synthesis of isothiazol-3-one derivatives as inhibitors of histone acetyltransferases (HATs)Stephen Gorsuch, Vassilios Bavetsias, Martin G Rowlands, et al.
Plos One|September 18, 2012
Co-crystalization and in vitro biological characterization of 5-aryl-4-(5-substituted-2-4-dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitorsSwee Y Sharp, S Mark Roe, Egidijus Kazlauskas, et al.
Assay and Drug Development Technologies|June 24, 2005
Solid-phase immunoassays in mechanism-based drug discovery: their application in the development of inhibitors of the molecular chaperone heat-shock protein 90Anthea Hardcastle, Kathy Boxall, Juliet Richards, et al.
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