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Plos Biology|March 22, 2017
Selective stalling of human translation through small-molecule engagement of the ribosome nascent chainNathanael G Lintner, Kim F McClure, Donna Petersen, et al.Journal of Medicinal Chemistry|March 4, 2017
Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA)Ariamala Gopalsamy, Arjun Narayanan, Shenping Liu, et al.ACS Medicinal Chemistry Letters|June 6, 2014
Chemical Probe Identification Platform for Orphan GPCRs Using Focused Compound Screening: GPR39 as a Case ExampleMarkus Boehm, David Hepworth, Paula M Loria, et al.Journal of Medicinal Chemistry|April 4, 2015
Short Hydrophobic Peptides with Cyclic Constraints Are Potent Glucagon-like Peptide-1 Receptor (GLP-1R) AgonistsHuy N Hoang, Kun Song, Timothy A Hill, et al.ACS Medicinal Chemistry Letters|February 21, 2015
Evaluation and synthesis of polar aryl- and heteroaryl spiroazetidine-piperidine acetamides as ghrelin inverse agonistsSuvi T M Orr, Ramsay Beveridge, Samit K Bhattacharya, et al.Journal of Medicinal Chemistry|April 18, 2014
Identification of (R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxynicotinic acid, a highly potent and selective nonsteroidal mineralocorticoid receptor antagonistAgustin Casimiro-Garcia, David W Piotrowski, Catherine Ambler, et al.ACS Medicinal Chemistry Letters|December 1, 2015
Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic TreatmentMark Ammirati, Scott W Bagley, Samit K Bhattacharya, et al.ACS Medicinal Chemistry Letters|June 6, 2014
Discovery of PF-5190457, a Potent, Selective, and Orally Bioavailable Ghrelin Receptor Inverse Agonist Clinical CandidateSamit K Bhattacharya, Kim Andrews, Ramsay Beveridge, et al.Journal of Medicinal Chemistry|June 1, 2022
A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 ReceptorDavid A Griffith, David J Edmonds, Jean-Philippe Fortin, et al.Angewandte Chemie (International Ed. in English)|October 27, 2017
Liver-Targeted Small-Molecule Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9 SynthesisKim F McClure, David W Piotrowski, Donna Petersen, et al.Pageof 4