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ACS Medicinal Chemistry Letters|February 18, 2026
Design of a Targeted Covalent Probe to Interrogate the DNA Polymerase Activity of PolθMonica Bubenik, Pavel Mader, Stephen Orlicky, et al.
ACS Chemical Biology|January 16, 2015
Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1Michael T Perfetti, Brandi M Baughman, Bradley M Dickson, et al.
Nature Chemical Biology|April 9, 2026
The molecular glue CLEO4-88 inhibits the ACAA1 thiolase by induced binding to GID4Chetan K Chana, Ines Ben Makhlouf, Jaeyoun Kim, et al.
Bioorganic & Medicinal Chemistry|July 23, 2019
Identification and characterization of the first fragment hits for SETDB1 Tudor domainPavel Mader, Rodrigo Mendoza-Sanchez, Aman Iqbal, et al.
Journal of Medicinal Chemistry|September 19, 2022
Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4Chetan K Chana, Pierre Maisonneuve, Ganna Posternak, et al.
Nature Chemical Biology|August 12, 2020
Functional characterization of a PROTAC directed against BRAF mutant V600EGanna Posternak, Xiaojing Tang, Pierre Maisonneuve, et al.
Journal of Medicinal Chemistry|July 26, 2022
Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306Janek Szychowski, Robert Papp, Evelyne Dietrich, et al.
Journal of Medicinal Chemistry|May 16, 2025
Discovery of RP-1664: A First-in-Class Orally Bioavailable, Selective PLK4 InhibitorFrédéric Vallée, Matias Casás-Selves, Monica Bubenik, et al.
Journal of Medicinal Chemistry|September 8, 2025
The Discovery of RP-2119: A Potent, Selective, and Orally Bioavailable Polθ ATPase InhibitorPhilippe Mochirian, Robert Papp, Marie-Claude Mathieu, et al.
Journal of Medicinal Chemistry|September 20, 2022
Identification of <b>RP-6685</b>, an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of PolθMonica Bubenik, Pavel Mader, Philippe Mochirian, et al.
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