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Analytical Biochemistry|September 21, 2014
A universal homogeneous assay for high-throughput determination of binding kineticsFelix Schiele, Pelin Ayaz, Amaury Fernández-MontalvánBiochemistry|September 6, 2011
Design, overexpression, and purification of polymerization-blocked yeast αβ-tubulin mutantsVinu Johnson, Pelin Ayaz, Patrick Huddleston, et al.Science (New York, N.Y.)|August 21, 2012
A TOG:αβ-tubulin complex structure reveals conformation-based mechanisms for a microtubule polymerasePelin Ayaz, Xuecheng Ye, Patrick Huddleston, et al.ACS Chemical Biology|April 20, 2016
Conformational Adaption May Explain the Slow Dissociation Kinetics of Roniciclib (BAY 1000394), a Type I CDK Inhibitor with Kinetic Selectivity for CDK2 and CDK9Pelin Ayaz, Dorothee Andres, Dennis A Kwiatkowski, et al.Elife|August 7, 2014
A tethered delivery mechanism explains the catalytic action of a microtubule polymerasePelin Ayaz, Sarah Munyoki, Elisabeth A Geyer, et al.Nature Communications|August 17, 2021
Structural basis for ALK2/BMPR2 receptor complex signaling through kinase domain oligomerizationChristopher Agnew, Pelin Ayaz, Risa Kashima, et al.Nature Communications|April 5, 2023
Structural mechanism of a drug-binding process involving a large conformational change of the protein targetPelin Ayaz, Agatha Lyczek, YiTing Paung, et al.Cell Reports|February 2, 2022
Targetable HER3 functions driving tumorigenic signaling in HER2-amplified cancersMarcia R Campbell, Ana Ruiz-Saenz, Elliott Peterson, et al.Journal of Medicinal Chemistry|July 17, 2020
Structural Basis of AZD9291 Selectivity for EGFR T790MXiao-E Yan, Pelin Ayaz, Su-Jie Zhu, et al.Proceedings of the National Academy of Sciences of the United States of America|February 1, 2024
Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2Heike Schönherr, Pelin Ayaz, Alexander M Taylor, et al.Pageof 2