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Expert Opinion on Drug Discovery|July 20, 2013
Predictive approaches to increase absorption of compounds during lead optimisationKlara Valko, James Butler, Peter Eddershaw
Pharmaceutical Research|July 13, 2016
Development of a Novel Quantitative Structure-Activity Relationship Model to Accurately Predict Pulmonary Absorption and Replace Routine Use of the Isolated Perfused Respiring Rat Lung ModelChris D Edwards, Chris Luscombe, Peter Eddershaw, et al.
Journal of Pharmaceutical Sciences|May 15, 2013
Selectivity in the impact of P-glycoprotein upon pulmonary absorption of airway-dosed substrates: a study in ex vivo lung models using chemical inhibition and genetic knockoutGhaith Al-Jayyoussi, Daniel F Price, Danielle Francombe, et al.
Bioorganic & Medicinal Chemistry Letters|December 17, 2008
Studies on a series of potent, orally bioavailable, 5-HT(1) receptor ligands--part IISimon E Ward, Peter Eddershaw, Sean T Flynn, et al.
Pharmacology Research & Perspectives|February 14, 2022
Application of a high-resolution in vitro human MDR1-MDCK assay and in vivo studies in preclinical species to improve prediction of CNS drug penetrationLicong Jiang, Sanjeev Kumar, Marc Nuechterlein, et al.
The AAPS Journal|July 19, 2022
Current Approaches for Predicting Human PK for Small Molecule Development Candidates: Findings from the IQ Human PK Prediction Working Group SurveyCarl Petersson, Xin Zhou, Joerg Berghausen, et al.
Bioorganic & Medicinal Chemistry Letters|November 7, 2006
Studies towards the identification of a new generation of atypical antipsychotic agentsVincenzo Garzya, Ian T Forbes, Andrew D Gribble, et al.
Bioorganic & Medicinal Chemistry Letters|March 23, 2021
The development of highly potent and selective small molecule correctors of Z α<sub>1</sub>-antitrypsin misfoldingJohn Liddle, Andrew C Pearce, Christopher Arico-Muendel, et al.
EMBO Molecular Medicine|January 29, 2021
Development of a small molecule that corrects misfolding and increases secretion of Z α<sub>1</sub> -antitrypsinDavid A Lomas, James A Irving, Christopher Arico-Muendel, et al.
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