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Proceedings of the National Academy of Sciences of the United States of America|December 29, 2007
The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasisAaron D Gitler, Brooke J Bevis, James Shorter, et al.
Human Molecular Genetics|September 16, 2017
Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cellsUlf Dettmer, Nagendran Ramalingam, Victoria E von Saucken, et al.
Nature Genetics|February 24, 2009
Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicityEsti Yeger-Lotem, Laura Riva, Linhui Julie Su, et al.
Journal of Medicinal Chemistry|March 15, 2014
Structure-activity relationships for withanolides as inducers of the cellular heat-shock responseE M Kithsiri Wijeratne, Ya-Ming Xu, Ruth Scherz-Shouval, et al.
Bioorganic & Medicinal Chemistry Letters|August 2, 2011
Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolatesWillmen Youngsaye, Benjamin Vincent, Cathy L Hartland, et al.
The EMBO Journal|March 29, 2011
The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replicationUlrike K Resenberger, Anja Harmeier, Andreas C Woerner, et al.
Cell|October 24, 2017
A Genetic Tool to Track Protein Aggregates and Control Prion InheritanceGregory A Newby, Szilvia Kiriakov, Erinc Hallacli, et al.
Nature Biomedical Engineering|August 7, 2023
Computational optimization of antibody humanness and stability by systematic energy-based rankingAriel Tennenhouse, Lev Khmelnitsky, Razi Khalaila, et al.
Nature Communications|July 1, 2022
Co-optimization of therapeutic antibody affinity and specificity using machine learning models that generalize to novel mutational spaceEmily K Makowski, Patrick C Kinnunen, Jie Huang, et al.
Briefings in Bioinformatics|January 24, 2025
Deep learning-based design and experimental validation of a medicine-like human antibody libraryNandhini Rajagopal, Udit Choudhary, Kenny Tsang, et al.
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