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Drug Metabolism and Disposition: the Biological Fate of Chemicals|January 27, 2010
Bioactivation of a novel 2-methylindole-containing dual chemoattractant receptor-homologous molecule expressed on T-helper type-2 cells/D-prostanoid receptor antagonist leads to mechanism-based CYP3A inactivation: glutathione adduct characterization and prediction of in vivo drug-drug interactionSimon G Wong, Peter W Fan, Raju Subramanian, et al.
ACS Medicinal Chemistry Letters|August 20, 2015
Probing Mechanisms of CYP3A Time-Dependent Inhibition Using a Truncated Model SystemXiaojing Wang, Minghua Sun, Connie New, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|May 1, 2020
Regional Proteomic Quantification of Clinically Relevant Non-Cytochrome P450 Enzymes along the Human Small IntestineHaeyoung Zhang, Chris Wolford, Abdul Basit, et al.
Molecular Pharmaceutics|September 21, 2020
Characterization of Differential Tissue Abundance of Major Non-CYP Enzymes in HumanAbdul Basit, Naveen K Neradugomma, Christopher Wolford, et al.
Chemical Research in Toxicology|September 13, 2011
Novel mechanism for dehalogenation and glutathione conjugation of dihalogenated anilines in human liver microsomes: evidence for ipso glutathione additionChenghong Zhang, Jane R Kenny, Hoa Le, et al.
Bioorganic & Medicinal Chemistry Letters|May 15, 2014
Solving time-dependent CYP3A4 inhibition for a series of indole-phenylacetic acid dual antagonists of the PGD(2) receptors CRTH2 and DPMichael G Johnson, Jim Jiwen Liu, An-Rong Li, et al.
Drug Metabolism Letters|April 12, 2016
Rate-Determining and Rate-Limiting Steps in the Clearance and Excretion of a Potent and Selective p21-Activated Kinase Inhibitor: A Case Study of Rapid Hepatic Uptake and Slow Elimination in RatPeter W Fan, Jacob Z Chen, M Allan Jaochico, et al.
Journal of Medicinal Chemistry|June 2, 2015
Structure-Guided Design of Group I Selective p21-Activated Kinase InhibitorsJames J Crawford, Wendy Lee, Ignacio Aliagas, et al.
ACS Medicinal Chemistry Letters|September 16, 2021
Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-OncologyMin Lu, Hongjun Zhang, Derun Li, et al.
Bioorganic & Medicinal Chemistry Letters|April 27, 2023
Filling a nick in NIK: Extending the half-life of a NIK inhibitor through structure-based drug designJames J Crawford, Jianwen Feng, Hans D Brightbill, et al.
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