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Biochemical Pharmacology|December 31, 2021
Off-target lipid metabolism disruption by the mouse constitutive androstane receptor ligand TCPOBOP in humanized miceJosef Skoda, Klara Dohnalova, Karel Chalupsky, et al.
European Journal of Pharmacology|July 29, 2008
SB203580, a pharmacological inhibitor of p38 MAP kinase transduction pathway activates ERK and JNK MAP kinases in primary cultures of human hepatocytesPavla Henklova, Radim Vrzal, Barbora Papouskova, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|April 14, 2018
Effect of Endocannabinoid Oleamide on Rat and Human Liver Cytochrome P450 Enzymes in In Vitro and In Vivo ModelsGabriela Dovrtelova, Ondrej Zendulka, Kristyna Noskova, et al.
Cells|December 1, 2020
Diazepam Promotes Translocation of Human Constitutive Androstane Receptor (CAR) via Direct Interaction with the Ligand-Binding DomainJosef Skoda, Jan Dusek, Martin Drastik, et al.
Journal of Medicinal Chemistry|May 5, 2016
2-(3-Methoxyphenyl)quinazoline Derivatives: A New Class of Direct Constitutive Androstane Receptor (CAR) AgonistsTomas Smutny, Alice Nova, Marcela Drechslerová, et al.
World Journal of Gastroenterology|December 7, 2017
Resveratrol modifies biliary secretion of cholephilic compounds in sham-operated and cholestatic ratsEva Dolezelova, Alena Prasnicka, Jolana Cermanova, et al.
Pharmacogenetics and Genomics|November 16, 2016
The plausible association of MTHFR and ADORA2A polymorphisms with nodules in rheumatoid arthritis patients treated with methotrexateTomas Soukup, Martin Dosedel, Jana Nekvindova, et al.
Molecular Nutrition & Food Research|February 20, 2022
Gene Expression Profiling of 1α,25(OH)2 D3 Treatment in 2D/3D Human Hepatocyte Models Reveals CYP3A4 Induction but Minor Changes in Other Xenobiotic-Metabolizing GenesPetr Pavek, Jan Dusek, Tomas Smutny, et al.
Toxicology Letters|June 7, 2019
Stilbene compound trans-3,4,5,4´-tetramethoxystilbene, a potential anticancer drug, regulates constitutive androstane receptor (Car) target genes, but does not possess proliferative activity in mouse liverJan Dusek, Josef Skoda, Ondrej Holas, et al.
Toxicology Letters|November 6, 2018
Trans-resveratrol, but not other natural stilbenes occurring in food, carries the risk of drug-food interaction via inhibition of cytochrome P450 enzymes or interaction with xenosensor receptorsLucie Hyrsova, Alena Vanduchova, Jan Dusek, et al.
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