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Cell Reports|October 16, 2025
P-Rex1 limits the agonist-induced internalization of GPCRs independently of its Rac-GEF activityMartin J Baker, Elizabeth Hampson, Priota Islam, et al.Journal of Medicinal Chemistry|June 25, 2005
Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based designBrian W Dymock, Xavier Barril, Paul A Brough, et al.The FEBS Journal|December 25, 2023
Small-molecule positive allosteric modulation of homomeric kainate receptors GluK1-3: development of screening assays and insight into GluK3 structureYasmin Bay, Raminta Venskutonytė, Stine M Frantsen, et al.Plos One|October 15, 2021
The structure of nontypeable Haemophilus influenzae SapA in a closed conformation reveals a constricted ligand-binding cavity and a novel RNA binding motifPetra Lukacik, C David Owen, Gemma Harris, et al.Chemistry & Biology|June 26, 2004
Structure-activity relationships in purine-based inhibitor binding to HSP90 isoformsLisa Wright, Xavier Barril, Brian Dymock, et al.Chemmedchem|February 3, 2025
Structure-Atropisomer Stability Relationship in Selective MCL-1 InhibitorsSzabolcs Sipos, Barbara Balazs, Tamas Gati, et al.Angewandte Chemie (International Ed. in English)|February 11, 2025
Binding-Site Purification of Actives (B-SPA) Enables Efficient Large-Scale Progression of Fragment Hits by Combining Multi-Step Array Synthesis With HT CrystallographyHarold Grosjean, Anthony Aimon, Storm Hassell-Hart, et al.Journal of Medicinal Chemistry|June 18, 2021
Fragment-Derived Selective Inhibitors of Dual-Specificity Kinases DYRK1A and DYRK1BDavid Lee Walmsley, James B Murray, Pawel Dokurno, et al.Journal of Medicinal Chemistry|May 12, 2021
Structure-Guided Discovery of Potent and Selective DYRK1A InhibitorsCsaba Weber, Melinda Sipos, Attila Paczal, et al.ACS Omega|September 9, 2021
The Effect of Core Replacement on S64315, a Selective MCL-1 Inhibitor, and Its AnaloguesSzabolcs Sipos, Balázs Bálint, Zoltán B Szabó, et al.Pageof 23