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Biochemical Pharmacology
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March 15, 2011
KS900: A hypoxia-directed, reductively activated methylating antitumor prodrug that selectively ablates O(6)-alkylguanine-DNA alkyltransferase in neoplastic cells
Raymond P Baumann, Kimiko Ishiguro, Philip G Penketh, et al.
Chemical Research in Toxicology
|
March 13, 2014
Influence of phosphate and phosphoesters on the decomposition pathway of 1,2-bis(methylsulfonyl)-1-(2-chloroethyhydrazine (90CE), the active anticancer moiety generated by Laromustine, KS119, and KS119W
Philip G Penketh, Krishnamurthy Shyam, Rui Zhu, et al.
The Journal of Biological Chemistry
|
May 25, 2004
Nuclear overexpression of NAD(P)H:quinone oxidoreductase 1 in Chinese hamster ovary cells increases the cytotoxicity of mitomycin C under aerobic and hypoxic conditions
Helen A Seow, Philip G Penketh, Michael F Belcourt, et al.
Leukemia Research
|
May 16, 2008
Lethality to leukemia cell lines of DNA interstrand cross-links generated by Cloretazine derived alkylating species
Philip G Penketh, Raymond P Baumann, Kimiko Ishiguro, et al.
Biochemical Pharmacology
|
July 27, 2010
Quantitative relationship between guanine O(6)-alkyl lesions produced by Onrigin™ and tumor resistance by O(6)-alkylguanine-DNA alkyltransferase
Kimiko Ishiguro, Yong-Lian Zhu, Krishnamurthy Shyam, et al.
Chemical Biology & Drug Design
|
June 22, 2017
pH-dependent general base catalyzed activation rather than isocyanate liberation may explain the superior anticancer efficacy of laromustine compared to related 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine prodrugs
Philip G Penketh, Richard A Finch, Rachel Sauro, et al.
Biochemical Pharmacology
|
December 17, 2009
Reductive activation of the prodrug 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine (KS119) selectively occurs in oxygen-deficient cells and overcomes O(6)-alkylguanine-DNA alkyltransferase mediated KS119 tumor cell resistance
Raymond P Baumann, Philip G Penketh, Kimiko Ishiguro, et al.
Chemical Research in Toxicology
|
July 12, 2014
Influence of glutathione and glutathione S-transferases on DNA interstrand cross-link formation by 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine, the active anticancer moiety generated by laromustine
Philip G Penketh, Eric Patridge, Krishnamurthy Shyam, et al.
Bioorganic & Medicinal Chemistry Letters
|
February 12, 2013
Chloroethylating and methylating dual function antineoplastic agents display superior cytotoxicity against repair proficient tumor cells
Rui Zhu, Raymond P Baumann, Eric Patridge, et al.
Analytical Biochemistry
|
May 19, 2016
When alcohol is the answer: Trapping, identifying and quantifying simple alkylating species in aqueous environments
Philip G Penketh, Krishnamurthy Shyam, Raymond P Baumann, et al.
Page
of 4
Search research articles
Search
Showing results (11-20 of 33) with videos related to
Sort By:
Page
of 4
Biochemical Pharmacology
|
March 15, 2011
KS900: A hypoxia-directed, reductively activated methylating antitumor prodrug that selectively ablates O(6)-alkylguanine-DNA alkyltransferase in neoplastic cells
Raymond P Baumann, Kimiko Ishiguro, Philip G Penketh, et al.
Chemical Research in Toxicology
|
March 13, 2014
Influence of phosphate and phosphoesters on the decomposition pathway of 1,2-bis(methylsulfonyl)-1-(2-chloroethyhydrazine (90CE), the active anticancer moiety generated by Laromustine, KS119, and KS119W
Philip G Penketh, Krishnamurthy Shyam, Rui Zhu, et al.
The Journal of Biological Chemistry
|
May 25, 2004
Nuclear overexpression of NAD(P)H:quinone oxidoreductase 1 in Chinese hamster ovary cells increases the cytotoxicity of mitomycin C under aerobic and hypoxic conditions
Helen A Seow, Philip G Penketh, Michael F Belcourt, et al.
Leukemia Research
|
May 16, 2008
Lethality to leukemia cell lines of DNA interstrand cross-links generated by Cloretazine derived alkylating species
Philip G Penketh, Raymond P Baumann, Kimiko Ishiguro, et al.
Biochemical Pharmacology
|
July 27, 2010
Quantitative relationship between guanine O(6)-alkyl lesions produced by Onrigin™ and tumor resistance by O(6)-alkylguanine-DNA alkyltransferase
Kimiko Ishiguro, Yong-Lian Zhu, Krishnamurthy Shyam, et al.
Chemical Biology & Drug Design
|
June 22, 2017
pH-dependent general base catalyzed activation rather than isocyanate liberation may explain the superior anticancer efficacy of laromustine compared to related 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine prodrugs
Philip G Penketh, Richard A Finch, Rachel Sauro, et al.
Biochemical Pharmacology
|
December 17, 2009
Reductive activation of the prodrug 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine (KS119) selectively occurs in oxygen-deficient cells and overcomes O(6)-alkylguanine-DNA alkyltransferase mediated KS119 tumor cell resistance
Raymond P Baumann, Philip G Penketh, Kimiko Ishiguro, et al.
Chemical Research in Toxicology
|
July 12, 2014
Influence of glutathione and glutathione S-transferases on DNA interstrand cross-link formation by 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine, the active anticancer moiety generated by laromustine
Philip G Penketh, Eric Patridge, Krishnamurthy Shyam, et al.
Bioorganic & Medicinal Chemistry Letters
|
February 12, 2013
Chloroethylating and methylating dual function antineoplastic agents display superior cytotoxicity against repair proficient tumor cells
Rui Zhu, Raymond P Baumann, Eric Patridge, et al.
Analytical Biochemistry
|
May 19, 2016
When alcohol is the answer: Trapping, identifying and quantifying simple alkylating species in aqueous environments
Philip G Penketh, Krishnamurthy Shyam, Raymond P Baumann, et al.
Page
of 4