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British Journal of Clinical Pharmacology|March 12, 2011
Omalizumab decreases IgE production in patients with allergic (IgE-mediated) asthma; PKPD analysis of a biomarker, total IgEPhilip J Lowe, Didier RenardRegulatory Toxicology and Pharmacology : RTP|December 16, 2014
Revision of omalizumab dosing table for dosing every 4 instead of 2 weeks for specific ranges of bodyweight and baseline IgEPhilip J Lowe, Panayiotis Georgiou, Janice CanvinJournal of Pharmacokinetics and Pharmacodynamics|January 3, 2021
Improving priors for human monoclonal antibody linear pharmacokinetic parameters by using half-lives from non-human primatesVittal Shivva, Martin Fink, Philip J LoweClinical Pharmacology and Therapeutics|September 26, 2017
Two Case Studies on How Study Designs Can Be Made More Informative Using Modeling and Simulation ApproachesPhilip J Lowe, Martin Fink, Mark N MiltonBasic & Clinical Pharmacology & Toxicology|March 1, 2005
On the prediction of the human response: a recycled mechanistic pharmacokinetic/pharmacodynamic approachGuy M L Meno-Tetang, Philip J LoweJournal of Medicinal Chemistry|March 20, 2008
New approach to measure protein binding based on a parallel artificial membrane assay and human serum albuminElisabet Lázaro, Philip J Lowe, Xavier Briand, et al.British Journal of Clinical Pharmacology|August 8, 2009
Relationship between omalizumab pharmacokinetics, IgE pharmacodynamics and symptoms in patients with severe persistent allergic (IgE-mediated) asthmaPhilip J Lowe, Stacey Tannenbaum, Aurelie Gautier, et al.The AAPS Journal|February 22, 2011
From target selection to the minimum acceptable biological effect level for human study: use of mechanism-based PK/PD modeling to design safe and efficacious biologicsJing Yu, Helene Karcher, Adam L Feire, et al.British Journal of Clinical Pharmacology|November 14, 2006
A mechanism-based binding model for the population pharmacokinetics and pharmacodynamics of omalizumabNaoto Hayashi, Yuko Tsukamoto, William M Sallas, et al.Drug Metabolism and Pharmacokinetics|May 31, 2016
Ethnic sensitivity assessment of pharmacokinetics and pharmacodynamics of omalizumab with dosing table expansionWataru Honma, Aurélie Gautier, Ines Paule, et al.Pageof 2