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Journal of Medicinal Chemistry|October 20, 2007
Synthesis and evaluation of 3-aryloxymethyl-1,2-dimethylindole-4,7-diones as mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1) activityMarie A Colucci, Philip Reigan, David Siegel, et al.
Bioorganic & Medicinal Chemistry|May 25, 2021
N-Substituted pyrrolopyrimidines and purines as p90 ribosomal S6 protein kinase-2 (RSK2) inhibitorsKimberly A Casalvieri, Christopher J Matheson, Becka M Warfield, et al.
Trends in Endocrinology and Metabolism: TEM|May 20, 2011
Determinants of adipophilin function in milk lipid formation and secretionBrandi M Chong, Philip Reigan, Kasey D Mayle-Combs, et al.
European Journal of Medicinal Chemistry|April 26, 2020
Substituted oxindol-3-ylidenes as AMP-activated protein kinase (AMPK) inhibitorsChristopher J Matheson, Kimberly A Casalvieri, Donald S Backos, et al.
Chemico-Biological Interactions|December 19, 2012
Comparative genomics, molecular evolution and computational modeling of ALDH1B1 and ALDH2Brian C Jackson, Roger S Holmes, Donald S Backos, et al.
Biochemistry|July 2, 2011
Indolequinone inhibitors of NRH:quinone oxidoreductase 2. Characterization of the mechanism of inhibition in both cell-free and cellular systemsChao Yan, Marine Dufour, David Siegel, et al.
Chemical Research in Toxicology|June 24, 2009
In vitro and in silico characterization of peroxiredoxin 6 modified by 4-hydroxynonenal and 4-oxononenalJames R Roede, David L Carbone, Jonathan A Doorn, et al.
Molecular Cancer Therapeutics|August 8, 2006
5-Methoxy-1,2-dimethyl-3-[(4-nitrophenoxy)methyl]indole-4,7-dione, a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1, exhibits activity against human pancreatic cancer in vitro and in vivoDonna L Dehn, David Siegel, Khan Shoeb Zafar, et al.
Bioorganic & Medicinal Chemistry|August 26, 2018
Isoxazolo[3,4-d]pyridazinones positively modulate the metabotropic glutamate subtypes 2 and 4Christina Gates, Donald S Backos, Philip Reigan, et al.
Molecular Pharmacology|March 7, 2013
Identification of functionally relevant lysine residues that modulate human farnesoid X receptor activationAn-Qiang Sun, Yuhuan Luo, Donald S Backos, et al.
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