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Science Translational Medicine|July 26, 2019
Autoimmune pathways in mice and humans are blocked by pharmacological stabilization of the TYK2 pseudokinase domainJames R Burke, Lihong Cheng, Kathleen M Gillooly, et al.ACS Medicinal Chemistry Letters|March 21, 2019
Identification of Imidazo[1,2-b]pyridazine Derivatives as Potent, Selective, and Orally Active Tyk2 JH2 InhibitorsChunjian Liu, James Lin, Ryan Moslin, et al.Journal of Medicinal Chemistry|March 10, 2009
Novel tricyclic inhibitors of IkappaB kinaseJames Kempson, Steven H Spergel, Junqing Guo, et al.Journal of Medicinal Chemistry|July 19, 2019
Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165Stephen T Wrobleski, Ryan Moslin, Shuqun Lin, et al.Journal of Medicinal Chemistry|August 18, 2016
Small Molecule Reversible Inhibitors of Bruton's Tyrosine Kinase (BTK): Structure-Activity Relationships Leading to the Identification of 7-(2-Hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9H-carbazole-1-carboxamide (BMS-935177)George V De Lucca, Qing Shi, Qingjie Liu, et al.Journal of Medicinal Chemistry|December 2, 2020
Biologic-like In Vivo Efficacy with Small Molecule Inhibitors of TNFα Identified Using Scaffold Hopping and Structure-Based Drug Design ApproachesHai-Yun Xiao, Ning Li, James J-W Duan, et al.ACS Medicinal Chemistry Letters|November 20, 2020
Driving Potency with Rotationally Stable Atropisomers: Discovery of Pyridopyrimidinedione-Carbazole Inhibitors of BTKAnurag S Srivastava, Soo Ko, Scott H Watterson, et al.Journal of Medicinal Chemistry|March 21, 2019
Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton's Tyrosine Kinase (BTK)Scott H Watterson, Qingjie Liu, Myra Beaudoin Bertrand, et al.Journal of Medicinal Chemistry|September 2, 2016
Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton's Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked AtropisomersScott H Watterson, George V De Lucca, Qing Shi, et al.Plos One|June 18, 2014
Standardized metadata for human pathogen/vector genomic sequencesVivien G Dugan, Scott J Emrich, Gloria I Giraldo-Calderón, et al.Pageof 100