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ACS Chemical Neuroscience|July 8, 2016
Ac-Trp-DPhe(p-I)-Arg-Trp-NH2, a 250-Fold Selective Melanocortin-4 Receptor (MC4R) Antagonist over the Melanocortin-3 Receptor (MC3R), Affects Energy Homeostasis in Male and Female Mice DifferentlyCody J Lensing, Danielle N Adank, Skye R Doering, et al.Journal of Medicinal Chemistry|February 12, 2019
Discovery of Polypharmacological Melanocortin-3 and -4 Receptor Probes and Identification of a 100-Fold Selective nM MC3R Agonist versus a μM MC4R Partial AgonistKatlyn A Fleming, Katie T Freeman, Mike D Powers, et al.Journal of Medicinal Chemistry|April 22, 2021
Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput "Unbiased" Screening CampaignSkye R Doering, Katie Freeman, Ginamarie Debevec, et al.Journal of Medicinal Chemistry|February 13, 2014
Identification of tetrapeptides from a mixture based positional scanning library that can restore nM full agonist function of the L106P, I69T, I102S, A219V, C271Y, and C271R human melanocortin-4 polymorphic receptors (hMC4Rs)Erica M Haslach, Huisuo Huang, Marvin Dirain, et al.Journal of Medicinal Chemistry|October 1, 2021
Functional Mixture-Based Positional Scan Identifies a Library of Antagonist Tetrapeptide Sequences (LAtTeS) with Nanomolar Potency for the Melanocortin-4 Receptor and Equipotent with the Endogenous AGRP(86-132) AntagonistMark D Ericson, Skye R Doering, Courtney M Larson, et al.Journal of Medicinal Chemistry|April 29, 2017
Discovery of Mixed Pharmacology Melanocortin-3 Agonists and Melanocortin-4 Receptor Tetrapeptide Antagonist Compounds (TACOs) Based on the Sequence Ac-Xaa1-Arg-(pI)DPhe-Xaa4-NH2Skye R Doering, Katie T Freeman, Sathya M Schnell, et al.Pageof 4