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ACS Medicinal Chemistry Letters
|
June 16, 2022
Discovery of 1<i>H-</i>Pyrazole Biaryl Sulfonamides as Novel G2019S-LRRK2 Kinase Inhibitors
Robert K Leśniak, R Jeremy Nichols, Marcus Schonemann, et al.
European Journal of Medicinal Chemistry
|
September 1, 2022
Discovery of azaspirocyclic 1H-3,4,5-Trisubstitued pyrazoles as novel G2019S-LRRK2 selective kinase inhibitors
Robert K Leśniak, R Jeremy Nichols, Marcus Schonemann, et al.
The Biochemical Journal
|
July 21, 2010
14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization
R Jeremy Nichols, Nicolas Dzamko, Nicholas A Morrice, et al.
The Biochemical Journal
|
August 14, 2013
Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle
Evy Lobbestael, Jing Zhao, Iakov N Rudenko, et al.
Brain : a Journal of Neurology
|
December 19, 2017
Reduced LRRK2 in association with retromer dysfunction in post-mortem brain tissue from LRRK2 mutation carriers
Ye Zhao, Gayathri Perera, Junko Takahashi-Fujigasaki, et al.
The Journal of Biological Chemistry
|
February 24, 2019
Parkinson's disease-associated mutations in the GTPase domain of LRRK2 impair its nucleotide-dependent conformational dynamics
Chun-Xiang Wu, Jingling Liao, Yangshin Park, et al.
Proceedings of the National Academy of Sciences of the United States of America
|
March 5, 2014
Parkinson disease-associated mutation R1441H in LRRK2 prolongs the "active state" of its GTPase domain
Jingling Liao, Chun-Xiang Wu, Christopher Burlak, et al.
Movement Disorders : Official Journal of the Movement Disorder Society
|
December 3, 2016
LRRK2 levels and phosphorylation in Parkinson's disease brain and cases with restricted Lewy bodies
Nicolas Dzamko, Amanda M Gysbers, Rina Bandopadhyay, et al.
Frontiers in Molecular Neuroscience
|
January 3, 2024
PAK6-mediated phosphorylation of PPP2R2C regulates LRRK2-PP2A complex formation
Lucia Iannotta, Marco Emanuele, Giulia Favetta, et al.
Cells
|
March 25, 2022
A Phosphosite Mutant Approach on LRRK2 Links Phosphorylation and Dephosphorylation to Protective and Deleterious Markers, Respectively
Antoine Marchand, Alessia Sarchione, Panagiotis S Athanasopoulos, et al.
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Search research articles
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Showing results (21-30 of 34) with videos related to
Sort By:
Page
of 4
ACS Medicinal Chemistry Letters
|
June 16, 2022
Discovery of 1<i>H-</i>Pyrazole Biaryl Sulfonamides as Novel G2019S-LRRK2 Kinase Inhibitors
Robert K Leśniak, R Jeremy Nichols, Marcus Schonemann, et al.
European Journal of Medicinal Chemistry
|
September 1, 2022
Discovery of azaspirocyclic 1H-3,4,5-Trisubstitued pyrazoles as novel G2019S-LRRK2 selective kinase inhibitors
Robert K Leśniak, R Jeremy Nichols, Marcus Schonemann, et al.
The Biochemical Journal
|
July 21, 2010
14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization
R Jeremy Nichols, Nicolas Dzamko, Nicholas A Morrice, et al.
The Biochemical Journal
|
August 14, 2013
Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle
Evy Lobbestael, Jing Zhao, Iakov N Rudenko, et al.
Brain : a Journal of Neurology
|
December 19, 2017
Reduced LRRK2 in association with retromer dysfunction in post-mortem brain tissue from LRRK2 mutation carriers
Ye Zhao, Gayathri Perera, Junko Takahashi-Fujigasaki, et al.
The Journal of Biological Chemistry
|
February 24, 2019
Parkinson's disease-associated mutations in the GTPase domain of LRRK2 impair its nucleotide-dependent conformational dynamics
Chun-Xiang Wu, Jingling Liao, Yangshin Park, et al.
Proceedings of the National Academy of Sciences of the United States of America
|
March 5, 2014
Parkinson disease-associated mutation R1441H in LRRK2 prolongs the "active state" of its GTPase domain
Jingling Liao, Chun-Xiang Wu, Christopher Burlak, et al.
Movement Disorders : Official Journal of the Movement Disorder Society
|
December 3, 2016
LRRK2 levels and phosphorylation in Parkinson's disease brain and cases with restricted Lewy bodies
Nicolas Dzamko, Amanda M Gysbers, Rina Bandopadhyay, et al.
Frontiers in Molecular Neuroscience
|
January 3, 2024
PAK6-mediated phosphorylation of PPP2R2C regulates LRRK2-PP2A complex formation
Lucia Iannotta, Marco Emanuele, Giulia Favetta, et al.
Cells
|
March 25, 2022
A Phosphosite Mutant Approach on LRRK2 Links Phosphorylation and Dephosphorylation to Protective and Deleterious Markers, Respectively
Antoine Marchand, Alessia Sarchione, Panagiotis S Athanasopoulos, et al.
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