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Bioconjugate Chemistry|January 26, 2018
Immolation of p-Aminobenzyl Ether Linker and Payload Potency and Stability Determine the Cell-Killing Activity of Antibody-Drug Conjugates with Phenol-Containing PayloadsDonglu Zhang, Hoa Le, Josefa Dela Cruz-Chuh, et al.
Mabs|September 6, 2018
Preclinical pharmacokinetics and pharmacodynamics of DCLL9718A: An antibody-drug conjugate for the treatment of acute myeloid leukemiaDouglas D Leipold, Isabel Figueroa, Shabkhaiz Masih, et al.
Journal of Medicinal Chemistry|August 14, 2020
Systematic Variation of Pyrrolobenzodiazepine (PBD)-Dimer Payload Physicochemical Properties Impacts Efficacy and Tolerability of the Corresponding Antibody-Drug ConjugatesLeanna R Staben, Jinhua Chen, Josefa Dela Cruz-Chuh, et al.
Journal of Medicinal Chemistry|November 8, 2017
Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-LinkersStephen J Gregson, Luke A Masterson, Binqing Wei, et al.
ACS Medicinal Chemistry Letters|November 25, 2016
Linker Immolation Determines Cell Killing Activity of Disulfide-Linked Pyrrolobenzodiazepine Antibody-Drug ConjugatesDonglu Zhang, Thomas H Pillow, Yong Ma, et al.
ACS Medicinal Chemistry Letters|October 24, 2017
Stabilizing a Tubulysin Antibody-Drug Conjugate To Enable Activity Against Multidrug-Resistant TumorsLeanna R Staben, Shang-Fan Yu, Jinhua Chen, et al.
Molecular Cancer Therapeutics|March 16, 2021
Calicheamicin Antibody-Drug Conjugates with Improved PropertiesBreanna S Vollmar, Chris Frantz, Melissa M Schutten, et al.
Molecular Cancer Therapeutics|December 29, 2017
An Anti-GDNF Family Receptor Alpha 1 (GFRA1) Antibody-Drug Conjugate for the Treatment of Hormone Receptor-Positive Breast CancerSunil Bhakta, Lisa M Crocker, Yvonne Chen, et al.
Cancer Cell|January 16, 2007
AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patientsTracy T Batchelor, A Gregory Sorensen, Emmanuelle di Tomaso, et al.
Nature Chemistry|November 23, 2016
Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugatesLeanna R Staben, Stefan G Koenig, Sophie M Lehar, et al.
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