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Nature Metabolism|November 24, 2020
An enolase inhibitor for the targeted treatment of ENO1-deleted cancersYu-Hsi Lin, Nikunj Satani, Naima Hammoudi, et al.
Cancer Discovery|August 21, 2020
BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK InhibitionMarco H Hofmann, Michael Gmachl, Juergen Ramharter, et al.
Journal of Medicinal Chemistry|July 22, 2021
Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) ApoenzymeMatthew M Hamilton, Faika Mseeh, Timothy J McAfoos, et al.
Oncoimmunology|November 15, 2021
Short-term treatment with multi-drug regimens combining BRAF/MEK-targeted therapy and immunotherapy results in durable responses in <i>Braf</i>-mutated melanomaMichael G White, Robert Szczepaniak Sloane, Russell G Witt, et al.
Cell Reports|January 10, 2019
Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative PhosphorylationYuting Sun, Madhavi Bandi, Timothy Lofton, et al.
Nature Cancer|August 5, 2024
Co-targeting SOS1 enhances the antitumor effects of KRAS<sup>G12C</sup> inhibitors by addressing intrinsic and acquired resistanceVenu Thatikonda, Hengyu Lyu, Sabine Jurado, et al.
Cancer Discovery|February 22, 2019
Molecular Profiling Reveals Unique Immune and Metabolic Features of Melanoma Brain MetastasesGrant M Fischer, Ali Jalali, David A Kircher, et al.
Nature Communications|July 31, 2021
PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinomaVirginia Giuliani, Meredith A Miller, Chiu-Yi Liu, et al.
The Journal of Experimental Medicine|March 24, 2021
Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemiaLucille Stuani, Marie Sabatier, Estelle Saland, et al.
Cancer Research|September 15, 2020
Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward OsimertinibYuting Sun, Brooke A Meyers, Barbara Czako, et al.
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