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Cell Chemical Biology|July 18, 2020
In Vitro and Cellular Probes to Study PARP Enzyme Target EngagementTim J Wigle, Danielle J Blackwell, Laurie B Schenkel, et al.
ACS Medicinal Chemistry Letters|May 19, 2016
Discovery of IWP-051, a Novel Orally Bioavailable sGC Stimulator with Once-Daily Dosing Potential in HumansTakashi Nakai, Nicholas R Perl, Timothy C Barden, et al.
Bioorganic & Medicinal Chemistry Letters|March 4, 2021
Discovery of CYR715: A novel carboxylic acid-containing soluble guanylate cyclase stimulatorGlen R Rennie, Timothy C Barden, Sylvie G Bernier, et al.
Chembiochem : a European Journal of Chemical Biology|April 10, 2021
Targeted Degradation of PARP14 Using a Heterobifunctional Small MoleculeTim J Wigle, Yue Ren, Jennifer R Molina, et al.
Nature Communications|September 26, 2023
PARP14 inhibition restores PD-1 immune checkpoint inhibitor response following IFNγ-driven acquired resistance in preclinical cancer modelsChun Wai Wong, Christos Evangelou, Kieran N Sefton, et al.
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