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Bioorganic & Medicinal Chemistry
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October 22, 2020
Improving metabolic stability and removing aldehyde oxidase liability in a 5-azaquinazoline series of IRAK4 inhibitors
Sébastien L Degorce, Anna Aagaard, Rana Anjum, et al.
Journal of Medicinal Chemistry
|
February 2, 2024
Identification of Novel, Selective Ataxia-Telangiectasia Mutated Kinase Inhibitors with the Ability to Penetrate the Blood-Brain Barrier: The Discovery of AZD1390
Kurt G Pike, Thomas A Hunt, Bernard Barlaam, et al.
Journal of Medicinal Chemistry
|
May 22, 2026
Use of Human Dose Prediction Metrics to Enable Discovery of AZD3470, an MTA-Cooperative PRMT5 Inhibitor in Clinical Evaluation
James M Smith, Bernard Barlaam, David Beattie, et al.
Journal of Medicinal Chemistry
|
August 12, 2024
Accelerated Discovery of Carbamate Cbl-b Inhibitors Using Generative AI Models and Structure-Based Drug Design
Taylor R Quinn, Kathryn A Giblin, Clare Thomson, et al.
Journal of Medicinal Chemistry
|
November 28, 2017
Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88<sup>L265P</sup> Diffuse Large B-Cell Lymphoma
James S Scott, Sébastien L Degorce, Rana Anjum, et al.
Nature Chemical Biology
|
October 25, 2016
Potent and selective bivalent inhibitors of BET bromodomains
Michael J Waring, Huawei Chen, Alfred A Rabow, et al.
ACS Medicinal Chemistry Letters
|
March 28, 2015
Pyrimidinone nicotinamide mimetics as selective tankyrase and wnt pathway inhibitors suitable for in vivo pharmacology
Jeffrey W Johannes, Lynsie Almeida, Bernard Barlaam, et al.
Journal of Medicinal Chemistry
|
May 10, 2017
Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors
William McCoull, Roman D Abrams, Erica Anderson, et al.
Journal of Medicinal Chemistry
|
July 18, 2017
Correction to Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors
William McCoull, Roman D Abrams, Erica Anderson, et al.
Journal of Medicinal Chemistry
|
March 11, 2024
Development of a Series of Pyrrolopyridone MAT2A Inhibitors
Stephen J Atkinson, Sharan K Bagal, Argyrides Argyrou, et al.
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Search research articles
Search
Showing results (61-70 of 74) with videos related to
Sort By:
Page
of 8
Bioorganic & Medicinal Chemistry
|
October 22, 2020
Improving metabolic stability and removing aldehyde oxidase liability in a 5-azaquinazoline series of IRAK4 inhibitors
Sébastien L Degorce, Anna Aagaard, Rana Anjum, et al.
Journal of Medicinal Chemistry
|
February 2, 2024
Identification of Novel, Selective Ataxia-Telangiectasia Mutated Kinase Inhibitors with the Ability to Penetrate the Blood-Brain Barrier: The Discovery of AZD1390
Kurt G Pike, Thomas A Hunt, Bernard Barlaam, et al.
Journal of Medicinal Chemistry
|
May 22, 2026
Use of Human Dose Prediction Metrics to Enable Discovery of AZD3470, an MTA-Cooperative PRMT5 Inhibitor in Clinical Evaluation
James M Smith, Bernard Barlaam, David Beattie, et al.
Journal of Medicinal Chemistry
|
August 12, 2024
Accelerated Discovery of Carbamate Cbl-b Inhibitors Using Generative AI Models and Structure-Based Drug Design
Taylor R Quinn, Kathryn A Giblin, Clare Thomson, et al.
Journal of Medicinal Chemistry
|
November 28, 2017
Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88<sup>L265P</sup> Diffuse Large B-Cell Lymphoma
James S Scott, Sébastien L Degorce, Rana Anjum, et al.
Nature Chemical Biology
|
October 25, 2016
Potent and selective bivalent inhibitors of BET bromodomains
Michael J Waring, Huawei Chen, Alfred A Rabow, et al.
ACS Medicinal Chemistry Letters
|
March 28, 2015
Pyrimidinone nicotinamide mimetics as selective tankyrase and wnt pathway inhibitors suitable for in vivo pharmacology
Jeffrey W Johannes, Lynsie Almeida, Bernard Barlaam, et al.
Journal of Medicinal Chemistry
|
May 10, 2017
Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors
William McCoull, Roman D Abrams, Erica Anderson, et al.
Journal of Medicinal Chemistry
|
July 18, 2017
Correction to Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors
William McCoull, Roman D Abrams, Erica Anderson, et al.
Journal of Medicinal Chemistry
|
March 11, 2024
Development of a Series of Pyrrolopyridone MAT2A Inhibitors
Stephen J Atkinson, Sharan K Bagal, Argyrides Argyrou, et al.
Page
of 8