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ACS Medicinal Chemistry Letters|July 19, 2023
Macrocyclic Carbon-Linked Pyrazoles As Novel Inhibitors of MCL-1Samuël Demin, Aldo Peschiulli, Adriana I Velter, et al.Journal of Medicinal Chemistry|April 28, 2023
Discovery of an Oral, Beyond-Rule-of-Five Mcl-1 Protein-Protein Interaction Modulator with the Potential of Treating Hematological MalignanciesFedor Romanov-Michailidis, Chien-Chi Hsiao, Lorenz M Urner, et al.ACS Medicinal Chemistry Letters|August 16, 2019
Evaluation of a Series of β-Secretase 1 Inhibitors Containing Novel Heteroaryl-Fused-Piperazine Amidine WarheadsDaniel Oehlrich, Aldo Peschiulli, Gary Tresadern, et al.Journal of Medicinal Chemistry|May 30, 2018
Optimization of 1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors Toward a Clinical CandidateHarrie J M Gijsen, Sergio A Alonso de Diego, Michel De Cleyn, et al.Journal of Medicinal Chemistry|January 21, 2017
Discovery of N-(Pyridin-4-yl)-1,5-naphthyridin-2-amines as Potential Tau Pathology PET Tracers for Alzheimer's DiseaseFrederik J R Rombouts, José-Ignacio Andrés, Manuela Ariza, et al.Journal of Medicinal Chemistry|September 23, 2021
JNJ-67569762, A 2-Aminotetrahydropyridine-Based Selective BACE1 Inhibitor Targeting the S3 Pocket: From Discovery to Clinical CandidateFrederik J R Rombouts, Ken-Ichi Kusakabe, Richard Alexander, et al.Journal of Medicinal Chemistry|September 18, 2015
1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors: From Hit Generation to Orally Bioavailable Brain Penetrant LeadsFrederik J R Rombouts, Gary Tresadern, Oscar Delgado, et al.Journal of Medicinal Chemistry|August 18, 2025
In Pursuit of Best-in-Class MCL-1 Inhibitors: Discovery of Highly Potent 1,4-Indoyl Macrocycles with Favorable Physicochemical PropertiesIngrid Adriana Velter, William Lento, Aldo Peschiulli, et al.Pageof 3