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Nature Reviews. Drug Discovery
|
April 2, 2011
Managing the challenge of chemically reactive metabolites in drug development
B Kevin Park, Alan Boobis, Stephen Clarke, et al.
ACS Medicinal Chemistry Letters
|
February 20, 2018
Late-Stage Microsomal Oxidation Reduces Drug-Drug Interaction and Identifies Phosphodiesterase 2A Inhibitor PF-06815189
Antonia F Stepan, Tuan P Tran, Christopher J Helal, et al.
Bioorganic & Medicinal Chemistry Letters
|
December 4, 2015
Design and optimization of selective azaindole amide M1 positive allosteric modulators
Jennifer E Davoren, Steven V O'Neil, Dennis P Anderson, et al.
Journal of Medicinal Chemistry
|
November 7, 2014
Chemical and computational methods for the characterization of covalent reactive groups for the prospective design of irreversible inhibitors
Mark E Flanagan, Joseph A Abramite, Dennis P Anderson, et al.
Journal of Medicinal Chemistry
|
October 15, 2011
Metabolism-directed design of oxetane-containing arylsulfonamide derivatives as γ-secretase inhibitors
Antonia F Stepan, Kapil Karki, W Scott McDonald, et al.
Journal of Medicinal Chemistry
|
April 24, 2015
The discovery and characterization of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor potentiator N-{(3S,4S)-4-[4-(5-cyano-2-thienyl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide (PF-04958242)
Christopher L Shaffer, Nandini C Patel, Jacob Schwarz, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals
|
October 27, 2004
The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model
Angela Doran, R Scott Obach, Bill J Smith, et al.
Journal of Medicinal Chemistry
|
September 25, 2009
Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections
Thomas V Magee, Sharon L Ripp, Bryan Li, et al.
Science (New York, N.Y.)
|
November 2, 2021
An oral SARS-CoV-2 M<sup>pro</sup> inhibitor clinical candidate for the treatment of COVID-19
Dafydd R Owen, Charlotte M N Allerton, Annaliesa S Anderson, et al.
Biorxiv : the Preprint Server for Biology
|
September 16, 2020
Discovery of a Novel Inhibitor of Coronavirus 3CL Protease for the Potential Treatment of COVID-19
Britton Boras, Rhys M Jones, Brandon J Anson, et al.
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Search research articles
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Showing results (181-190 of 193) with videos related to
Sort By:
Page
of 20
Nature Reviews. Drug Discovery
|
April 2, 2011
Managing the challenge of chemically reactive metabolites in drug development
B Kevin Park, Alan Boobis, Stephen Clarke, et al.
ACS Medicinal Chemistry Letters
|
February 20, 2018
Late-Stage Microsomal Oxidation Reduces Drug-Drug Interaction and Identifies Phosphodiesterase 2A Inhibitor PF-06815189
Antonia F Stepan, Tuan P Tran, Christopher J Helal, et al.
Bioorganic & Medicinal Chemistry Letters
|
December 4, 2015
Design and optimization of selective azaindole amide M1 positive allosteric modulators
Jennifer E Davoren, Steven V O'Neil, Dennis P Anderson, et al.
Journal of Medicinal Chemistry
|
November 7, 2014
Chemical and computational methods for the characterization of covalent reactive groups for the prospective design of irreversible inhibitors
Mark E Flanagan, Joseph A Abramite, Dennis P Anderson, et al.
Journal of Medicinal Chemistry
|
October 15, 2011
Metabolism-directed design of oxetane-containing arylsulfonamide derivatives as γ-secretase inhibitors
Antonia F Stepan, Kapil Karki, W Scott McDonald, et al.
Journal of Medicinal Chemistry
|
April 24, 2015
The discovery and characterization of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor potentiator N-{(3S,4S)-4-[4-(5-cyano-2-thienyl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide (PF-04958242)
Christopher L Shaffer, Nandini C Patel, Jacob Schwarz, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals
|
October 27, 2004
The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model
Angela Doran, R Scott Obach, Bill J Smith, et al.
Journal of Medicinal Chemistry
|
September 25, 2009
Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections
Thomas V Magee, Sharon L Ripp, Bryan Li, et al.
Science (New York, N.Y.)
|
November 2, 2021
An oral SARS-CoV-2 M<sup>pro</sup> inhibitor clinical candidate for the treatment of COVID-19
Dafydd R Owen, Charlotte M N Allerton, Annaliesa S Anderson, et al.
Biorxiv : the Preprint Server for Biology
|
September 16, 2020
Discovery of a Novel Inhibitor of Coronavirus 3CL Protease for the Potential Treatment of COVID-19
Britton Boras, Rhys M Jones, Brandon J Anson, et al.
Page
of 20