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Bioorganic & Medicinal Chemistry Letters|July 18, 2015
Further optimization of the mGlu5 PAM clinical candidate VU0409551/JNJ-46778212: Progress and challenges towards a back-up compoundYa Zhou, Chrysa Malosh, Susana Conde-Ceide, et al.
Bioorganic & Medicinal Chemistry Letters|May 22, 2012
Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAMDouglas J Sheffler, Cody J Wenthur, Joshua A Bruner, et al.
International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group|January 5, 2017
Quality assurance guidelines for superficial hyperthermia clinical trials: I. Clinical requirementsHana Dobšíček Trefná, Hans Crezee, Manfred Schmidt, et al.
Bioorganic & Medicinal Chemistry Letters|November 13, 2012
Discovery and SAR of a novel series of non-MPEP site mGlu₅ PAMs based on an aryl glycine sulfonamide scaffoldAlice L Rodriguez, Ya Zhou, Richard Williams, et al.
Bioorganic & Medicinal Chemistry Letters|June 26, 2014
Discovery and SAR of a novel series of metabotropic glutamate receptor 5 positive allosteric modulators with high ligand efficiencyMark Turlington, Meredith J Noetzel, Thomas M Bridges, et al.
International Journal of Radiation Oncology, Biology, Physics|February 11, 1998
Survival benefit of hyperthermia in a prospective randomized trial of brachytherapy boost +/- hyperthermia for glioblastoma multiformeP K Sneed, P R Stauffer, M W McDermott, et al.
The Journal of Pharmacology and Experimental Therapeutics|October 28, 2015
VU0477573: Partial Negative Allosteric Modulator of the Subtype 5 Metabotropic Glutamate Receptor with In Vivo EfficacyHilary Highfield Nickols, Joannes P Yuh, Karen J Gregory, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|September 5, 2013
Heterotropic activation of the midazolam hydroxylase activity of CYP3A by a positive allosteric modulator of mGlu5: in vitro to in vivo translation and potential impact on clinically relevant drug-drug interactionsAnna L Blobaum, Thomas M Bridges, Frank W Byers, et al.
Cell Host & Microbe|February 4, 2026
HMGB1 functions as a critical mediator of host defense at the gut mucosal barrierAnne-Marie C Overstreet, McKenzie Burge, Brady Anderson, et al.
ACS Chemical Neuroscience|April 28, 2018
A Novel M1 PAM VU0486846 Exerts Efficacy in Cognition Models without Displaying Agonist Activity or Cholinergic ToxicityJerri M Rook, Jeanette L Bertron, Hyekyung P Cho, et al.
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