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Bioorganic & Medicinal Chemistry Letters|February 17, 2015
Discovery and SAR of novel series of imidazopyrimidinones and dihydroimidazopyrimidinones as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5)María Luz Martín-Martín, José Manuel Bartolomé-Nebreda, Susana Conde-Ceide, et al.Molecular Pharmacology|October 7, 2010
Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activityAlice L Rodriguez, Mark D Grier, Carrie K Jones, et al.Bioorganic & Medicinal Chemistry Letters|January 30, 2007
Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind beta-secretase in a N-terminal 10s-loop down conformationShaun R Stauffer, Matthew G Stanton, Alison R Gregro, et al.Neuron|May 22, 2025
Machine learning identification of enhancers in the rhesus macaque genomeJing He, BaDoi N Phan, Willa G Kerkhoff, et al.Journal of Medicinal Chemistry|November 15, 2019
Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein InteractionJonathan D Macdonald, Selena Chacón Simon, Changho Han, et al.ACS Medicinal Chemistry Letters|July 10, 2015
Discovery of VU0409551/JNJ-46778212: An mGlu5 Positive Allosteric Modulator Clinical Candidate Targeting SchizophreniaSusana Conde-Ceide, Carlos M Martínez-Viturro, Jesús Alcázar, et al.Bioorganic & Medicinal Chemistry Letters|December 20, 2015
Preliminary investigation of 6,7-dihydropyrazolo[1,5-a]pyrazin-4-one derivatives as a novel series of mGlu5 receptor positive allosteric modulators with efficacy in preclinical models of schizophreniaSusana Conde-Ceide, Jesús Alcázar, Sergio A Alonso de Diego, et al.Bioorganic & Medicinal Chemistry Letters|March 18, 2018
Identification of second-generation P2X3 antagonists for treatment of painAnthony T Ginnetti, Daniel V Paone, Shaun R Stauffer, et al.Bioorganic & Medicinal Chemistry Letters|October 18, 2015
Acyl dihydropyrazolo[1,5-a]pyrimidinones as metabotropic glutamate receptor 5 positive allosteric modulatorsChrysa Malosh, Mark Turlington, Thomas M Bridges, et al.JCI Insight|May 5, 2026
Development and characterization of triazole-based WDR5 inhibitors for the treatment of glioblastomaJesse A Coker, Steven R Martinez, Sang Hoon Han, et al.Pageof 29