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Bioorganic & Medicinal Chemistry Letters|March 30, 2010
Imidazo[2,1-b]thiazoles: multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinasesSteve D Fidanze, Scott A Erickson, Gary T Wang, et al.Journal of Medicinal Chemistry|January 23, 1998
Discovery and evaluation of a series of 3-acylindole imidazopyridine platelet-activating factor antagonistsM L Curtin, S K Davidsen, H R Heyman, et al.Cancer Research|April 19, 2017
Preclinical Characterization of BET Family Bromodomain Inhibitor ABBV-075 Suggests Combination Therapeutic StrategiesMai H Bui, Xiaoyu Lin, Daniel H Albert, et al.Journal of Medicinal Chemistry|June 23, 2006
Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin bindingGeorge S Sheppard, Jieyi Wang, Megumi Kawai, et al.Cell Death & Disease|January 16, 2015
Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)J D Leverson, H Zhang, J Chen, et al.Bioorganic & Medicinal Chemistry Letters|April 22, 2018
Discovery and optimization of novel constrained pyrrolopyridone BET family inhibitorsSteven D Fidanze, Dachun Liu, Robert A Mantei, et al.Bioorganic & Medicinal Chemistry Letters|March 8, 2017
Methylpyrrole inhibitors of BET bromodomainsLisa A Hasvold, George S Sheppard, Le Wang, et al.Journal of Medicinal Chemistry|February 14, 2015
Structure-guided design of a series of MCL-1 inhibitors with high affinity and selectivityMilan Bruncko, Le Wang, George S Sheppard, et al.Journal of Medicinal Chemistry|September 27, 2017
Discovery of N-(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain InhibitorKeith F McDaniel, Le Wang, Todd Soltwedel, et al.Nature|January 24, 2020
Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancerEmily J Faivre, Keith F McDaniel, Daniel H Albert, et al.Pageof 21