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Current Opinion in Chemical Biology
|
May 2, 2021
Adapting protein sequences for optimized therapeutic efficacy
Nikki Dellas, Joyce Liu, Rachel C Botham, et al.
Nature Protocols
|
February 6, 2010
Preparation of the caspase-3/7 substrate Ac-DEVD-pNA by solution-phase peptide synthesis
Quinn P Peterson, David R Goode, Diana C West, et al.
Journal of the American Chemical Society
|
January 4, 2014
Dual small-molecule targeting of procaspase-3 dramatically enhances zymogen activation and anticancer activity
Rachel C Botham, Timothy M Fan, Isak Im, et al.
Journal of Medicinal Chemistry
|
April 10, 2015
Removal of Metabolic Liabilities Enables Development of Derivatives of Procaspase-Activating Compound 1 (PAC-1) with Improved Pharmacokinetics
Howard S Roth, Rachel C Botham, Steven C Schmid, et al.
ACS Central Science
|
September 10, 2016
Small-Molecule Procaspase-3 Activation Sensitizes Cancer to Treatment with Diverse Chemotherapeutics
Rachel C Botham, Howard S Roth, Alison P Book, et al.
ACS Combinatorial Science
|
October 20, 2011
Parallel synthesis and biological evaluation of 837 analogues of procaspase-activating compound 1 (PAC-1)
Danny C Hsu, Howard S Roth, Diana C West, et al.
Nature Chemistry
|
September 2, 2020
Using sulfuramidimidoyl fluorides that undergo sulfur(VI) fluoride exchange for inverse drug discovery
Gabriel J Brighty, Rachel C Botham, Suhua Li, et al.
Cell Reports
|
December 15, 2015
A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed
Rahul Palchaudhuri, Michael J Lambrecht, Rachel C Botham, et al.
Oncotarget
|
November 9, 2017
Synergistic and targeted therapy with a procaspase-3 activator and temozolomide extends survival in glioma rodent models and is feasible for the treatment of canine malignant glioma patients
Avadhut D Joshi, Rachel C Botham, Lisa J Schlein, et al.
Neuro-Oncology
|
July 3, 2021
Evaluation of a procaspase-3 activator with hydroxyurea or temozolomide against high-grade meningioma in cell culture and canine cancer patients
Emily J Tonogai, Shan Huang, Rachel C Botham, et al.
Page
of 2
Search research articles
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Showing results (1-10 of 11) with videos related to
Sort By:
Page
of 2
Current Opinion in Chemical Biology
|
May 2, 2021
Adapting protein sequences for optimized therapeutic efficacy
Nikki Dellas, Joyce Liu, Rachel C Botham, et al.
Nature Protocols
|
February 6, 2010
Preparation of the caspase-3/7 substrate Ac-DEVD-pNA by solution-phase peptide synthesis
Quinn P Peterson, David R Goode, Diana C West, et al.
Journal of the American Chemical Society
|
January 4, 2014
Dual small-molecule targeting of procaspase-3 dramatically enhances zymogen activation and anticancer activity
Rachel C Botham, Timothy M Fan, Isak Im, et al.
Journal of Medicinal Chemistry
|
April 10, 2015
Removal of Metabolic Liabilities Enables Development of Derivatives of Procaspase-Activating Compound 1 (PAC-1) with Improved Pharmacokinetics
Howard S Roth, Rachel C Botham, Steven C Schmid, et al.
ACS Central Science
|
September 10, 2016
Small-Molecule Procaspase-3 Activation Sensitizes Cancer to Treatment with Diverse Chemotherapeutics
Rachel C Botham, Howard S Roth, Alison P Book, et al.
ACS Combinatorial Science
|
October 20, 2011
Parallel synthesis and biological evaluation of 837 analogues of procaspase-activating compound 1 (PAC-1)
Danny C Hsu, Howard S Roth, Diana C West, et al.
Nature Chemistry
|
September 2, 2020
Using sulfuramidimidoyl fluorides that undergo sulfur(VI) fluoride exchange for inverse drug discovery
Gabriel J Brighty, Rachel C Botham, Suhua Li, et al.
Cell Reports
|
December 15, 2015
A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed
Rahul Palchaudhuri, Michael J Lambrecht, Rachel C Botham, et al.
Oncotarget
|
November 9, 2017
Synergistic and targeted therapy with a procaspase-3 activator and temozolomide extends survival in glioma rodent models and is feasible for the treatment of canine malignant glioma patients
Avadhut D Joshi, Rachel C Botham, Lisa J Schlein, et al.
Neuro-Oncology
|
July 3, 2021
Evaluation of a procaspase-3 activator with hydroxyurea or temozolomide against high-grade meningioma in cell culture and canine cancer patients
Emily J Tonogai, Shan Huang, Rachel C Botham, et al.
Page
of 2