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Experimental Neurology|June 30, 2020
LRRC8A-dependent volume-regulated anion channels contribute to ischemia-induced brain injury and glutamatergic input to hippocampal neuronsJing-Jing Zhou, Yi Luo, Shao-Rui Chen, et al.
Frontiers in Cardiovascular Medicine|August 26, 2021
Electrophysiological and Molecular Mechanisms of Sinoatrial Node MechanosensitivityDaniel Turner, Chen Kang, Pietro Mesirca, et al.
Nature Communications|March 27, 2023
Structural and functional analysis of human pannexin 2 channelZhihui He, Yonghui Zhao, Michael J Rau, et al.
Proceedings of the National Academy of Sciences of the United States of America|July 24, 2013
Ion channel-kinase TRPM7 is required for maintaining cardiac automaticityRajan Sah, Pietro Mesirca, Marjolein Van den Boogert, et al.
The Journal of Physiology|January 2, 2003
Regulation of cardiac excitation-contraction coupling by action potential repolarization: role of the transient outward potassium current (I(to))Rajan Sah, Rafael J Ramirez, Gavin Y Oudit, et al.
JCI Insight|February 7, 2023
Adipose-targeted SWELL1 deletion exacerbates obesity- and age-related nonalcoholic fatty liver diseaseSusheel K Gunasekar, John Heebink, Danielle H Carpenter, et al.
JCI Insight|March 15, 2017
The volume-regulated anion channel (LRRC8) in nodose neurons is sensitive to acidic pHRunping Wang, Yongjun Lu, Susheel Gunasekar, et al.
Iscience|May 14, 2023
Conditional deletion of LRRC8A in the brain reduces stroke damage independently of swelling-activated glutamate releaseMustafa Balkaya, Preeti Dohare, Sophie Chen, et al.
Science Translational Medicine|October 22, 2025
LRRC8A constitutively inhibits pain hypersensitivity in rodent models by restraining NMDA receptor activity at spinal cord synapsesMeichun Deng, Shao-Rui Chen, Meng-Hua Zhou, et al.
JCI Insight|April 29, 2025
LRRC8 channel complexes counterbalance KATP channels to mediate swell-secretion coupling in mouse pancreatic β cellsTarek Mohamed Abd El-Aziz, Chen Kang, Litao Xie, et al.
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