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Annals of Neurology|October 9, 2018
N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with prostaglandin E2 to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in miceSaravanan S Karuppagounder, Lauren Alin, Yingxin Chen, et al.
Annals of the New York Academy of Sciences|December 17, 2008
Small molecule activation of adaptive gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injuryRajiv R Ratan, Ambreena Siddiq, Leila Aminova, et al.
ACS Chemical Biology|April 9, 2014
A selective phenelzine analogue inhibitor of histone demethylase LSD1Polina Prusevich, Jay H Kalin, Shonoi A Ming, et al.
Acta Neuropathologica Communications|January 23, 2023
Parkin coregulates glutathione metabolism in adult mammalian brainDaniel N El Kodsi, Jacqueline M Tokarew, Rajib Sengupta, et al.
EMBO Molecular Medicine|July 29, 2010
Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington diseaseStephen J McConoughey, Manuela Basso, Zoya V Niatsetskaya, et al.
Neuron|October 1, 2024
Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy modelGillian K Carling, Li Fan, Nessa R Foxe, et al.
Nature Neuroscience|April 24, 2023
Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilienceJoe C Udeochu, Sadaf Amin, Yige Huang, et al.
Science Immunology|April 23, 2021
Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhageMichael H Askenase, Brittany A Goods, Hannah E Beatty, et al.
Science Translational Medicine|March 4, 2016
Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent modelsSaravanan S Karuppagounder, Ishraq Alim, Soah J Khim, et al.
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