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Molecular Cell|October 17, 2015
DNase H Activity of Neisseria meningitidis Cas9Yan Zhang, Rakhi Rajan, H Steven Seifert, et al.Cell Reports|December 28, 2017
RNA-Independent DNA Cleavage Activities of Cas9 and Cas12aRamya Sundaresan, Hari Priya Parameshwaran, S D Yogesha, et al.Peerj|April 11, 2017
Conserved DNA motifs in the type II-A CRISPR leader regionMason J Van Orden, Peter Klein, Kesavan Babu, et al.Biochemistry|March 28, 2019
Bridge Helix of Cas9 Modulates Target DNA Cleavage and Mismatch ToleranceKesavan Babu, Nadia Amrani, Wei Jiang, et al.Biochemistry|December 16, 2024
Exploring CRISPR-Cas9 HNH-Domain-Catalyzed DNA Cleavage Using Accelerated Quantum Mechanical Molecular Mechanical Free Energy SimulationRichard Van, Xiaoliang Pan, Saadi Rostami, et al.The CRISPR Journal|April 19, 2022
Rational Engineering of CRISPR-Cas9 Nuclease to Attenuate Position-Dependent Off-Target EffectsZhicheng Zuo, Kesavan Babu, Chhandosee Ganguly, et al.Journal of the American Chemical Society|December 23, 2008
Probing the catalytic mechanism of S-ribosylhomocysteinase (LuxS) with catalytic intermediates and substrate analoguesBhaskar Gopishetty, Jinge Zhu, Rakhi Rajan, et al.Nature Communications|January 28, 2026
Bridge helix of Cas12a is an allosteric regulator of R-loop formation and RuvC activationChhandosee Ganguly, Swarmistha Devi Aribam, Alberto Monteiro Dos Santos, et al.FEBS Letters|February 1, 2021
The bridge helix of Cas12a imparts selectivity in cis-DNA cleavage and regulates trans-DNA cleavageHari Priya Parameshwaran, Kesavan Babu, Christine Tran, et al.Elife|July 31, 2019
Structural and functional insights into the bona fide catalytic state of Streptococcus pyogenes Cas9 HNH nuclease domainZhicheng Zuo, Ashwini Zolekar, Kesavan Babu, et al.Pageof 4