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Bioorganic & Medicinal Chemistry Letters|August 17, 2010
The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: the second clinical candidate having a shorter and favorable human half-lifeJane L Wang, David Limburg, Matthew J Graneto, et al.The Biochemical Journal|December 5, 2015
Probing the enzyme kinetics, allosteric modulation and activation of α1- and α2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological and physiological activatorsFrancis Rajamohan, Allan R Reyes, Richard K Frisbie, et al.Bioorganic & Medicinal Chemistry Letters|May 26, 2005
Structure-based design and synthesis of pyrazinones containing novel P1 'side pocket' moieties as inhibitors of TF/VIIaBarbara A Schweitzer, William L Neumann, Hayat K Rahman, et al.Structure (London, England : 1993)|October 1, 2013
Activation of AMP-activated protein kinase revealed by hydrogen/deuterium exchange mass spectrometryRachelle R Landgraf, Devrishi Goswami, Francis Rajamohan, et al.Journal of Computer-Aided Molecular Design|September 9, 2008
Homo-timeric structural model of human microsomal prostaglandin E synthase-1 and characterization of its substrate/inhibitor binding interactionsLi Xing, Ravi G Kurumbail, Ronald B Frazier, et al.Bioorganic & Medicinal Chemistry Letters|August 13, 2014
Kinase domain inhibition of leucine rich repeat kinase 2 (LRRK2) using a [1,2,4]triazolo[4,3-b]pyridazine scaffoldPaul Galatsis, Jaclyn L Henderson, Bethany L Kormos, et al.Bioorganic & Medicinal Chemistry Letters|June 26, 2003
Structure-based drug design of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complexMichael S South, Brenda L Case, Rhonda S Wood, et al.Journal of Medicinal Chemistry|October 30, 2014
Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitorJaclyn L Henderson, Bethany L Kormos, Matthew M Hayward, et al.Journal of Medicinal Chemistry|July 24, 2018
Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK)Tim F Ryder, Matthew F Calabrese, Gregory S Walker, et al.Biochemistry|June 6, 2009
Structural bioinformatics-based prediction of exceptional selectivity of p38 MAP kinase inhibitor PH-797804Li Xing, Huey S Shieh, Shaun R Selness, et al.Pageof 5