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Bioorganic & Medicinal Chemistry|January 18, 2011
Aminopyridinecarboxamide-based inhaled IKK-2 inhibitors for asthma and COPD: Structure-activity relationshipJin Xie, Gennadiy I Poda, Yiding Hu, et al.Journal of Medicinal Chemistry|September 5, 2003
Design, parallel synthesis, and crystal structures of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complexJohn J Parlow, Brenda L Case, Thomas A Dice, et al.Journal of Medicinal Chemistry|October 24, 2007
Synthesis, crystal structure, and activity of pyrazole-based inhibitors of p38 kinaseMatthew J Graneto, Ravi G Kurumbail, Michael L Vazquez, et al.Journal of Medicinal Chemistry|September 20, 2019
Structural Basis for Achieving GSK-3β Inhibition with High Potency, Selectivity, and Brain Exposure for Positron Emission Tomography Imaging and Drug DiscoveryVadim Bernard-Gauthier, Andrew V Mossine, Ashley Knight, et al.The Biochemical Journal|March 6, 2014
Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitorsSeungil Han, Robert M Czerwinski, Nicole L Caspers, et al.Structure (London, England : 1993)|July 29, 2014
Structural basis for AMPK activation: natural and synthetic ligands regulate kinase activity from opposite poles by different molecular mechanismsMatthew F Calabrese, Francis Rajamohan, Melissa S Harris, et al.The Journal of Pharmacology and Experimental Therapeutics|March 15, 2017
Selective Activation of AMPK β1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic NephropathyChristopher T Salatto, Russell A Miller, Kimberly O Cameron, et al.Cell Metabolism|May 4, 2017
Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and MiceEmily C Cokorinos, Jake Delmore, Allan R Reyes, et al.Journal of Medicinal Chemistry|August 5, 2016
Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic NephropathyKimberly O Cameron, Daniel W Kung, Amit S Kalgutkar, et al.Angewandte Chemie (International Ed. in English)|June 30, 2016
Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET NeuroimagingSteven H Liang, Jinshan Michael Chen, Marc D Normandin, et al.Pageof 5