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Journal of Pharmacological and Toxicological Methods|April 15, 2021
The in vivo QTc core assay: An evaluation of QTc variability, detection sensitivity and implications for the improvement of conscious dog and non-human primate telemetry studiesJoel Baublits, Hugo M Vargas, Michael J EngwallJournal of Pharmacological and Toxicological Methods|September 6, 2011
hERG potency estimates based upon dose solution analysis: What have we learned?Yusheng Qu, Paul Schnier, Roger Zanon, et al.Expert Opinion on Drug Safety|November 23, 2012
Nonclinical strategy considerations for safety pharmacology: evaluation of biopharmaceuticalsHugo M Vargas, Hamid R Amouzadeh, Michael J EngwallJournal of Pharmacological and Toxicological Methods|March 23, 2013
Human embryonic stem cell derived cardiac myocytes detect hERG-mediated repolarization effects, but not Nav1.5 induced depolarization delayYusheng Qu, Baoxi Gao, Mei Fang, et al.Handbook of Experimental Pharmacology|June 21, 2015
Safety Pharmacology Evaluation of BiopharmaceuticalsHamid R Amouzadeh, Michael J Engwall, Hugo M VargasPharmacology Research & Perspectives|September 24, 2020
Effects of omecamtiv mecarbil on calcium-transients and contractility in a translational canine myocyte modelBaoXi Gao, Weston Sutherland, Hugo M Vargas, et al.Heart Rhythm|February 22, 2017
Bioelectronic neuromodulation of the paravertebral cardiac efferent sympathetic outflow and its effect on ventricular electrical indicesUna Buckley, Ray W Chui, Pradeep S Rajendran, et al.Heart Rhythm|June 21, 2017
Bioelectronic block of paravertebral sympathetic nerves mitigates post-myocardial infarction ventricular arrhythmiasRay W Chui, Una Buckley, Pradeep S Rajendran, et al.Frontiers in Cardiovascular Medicine|March 12, 2021
The Effects of Repeat-Dose Doxorubicin on Cardiovascular Functional Endpoints and Biomarkers in the Telemetry-Equipped Cynomolgus MonkeyMichael J Engwall, Nancy Everds, James R Turk, et al.Clinical and Translational Science|May 6, 2021
Comprehensive in vitro pro-arrhythmic assays demonstrate that omecamtiv mecarbil has low pro-arrhythmic riskYusheng Qu, BaoXi Gao, Ziva Arimura, et al.Pageof 7