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ACS Medicinal Chemistry Letters|June 6, 2014
Discovery of AMG 369, a Thiazolo[5,4-b]pyridine Agonist of S1P1 and S1P5Victor J Cee, Mike Frohn, Brian A Lanman, et al.ACS Medicinal Chemistry Letters|June 6, 2014
Discovery of a Potent, S1P3-Sparing Benzothiazole Agonist of Sphingosine-1-Phosphate Receptor 1 (S1P1)Brian A Lanman, Victor J Cee, Srinivasa R Cheruku, et al.ACS Medicinal Chemistry Letters|February 21, 2015
An Orally Available BACE1 Inhibitor That Affords Robust CNS Aβ Reduction without Cardiovascular LiabilitiesYuan Cheng, James Brown, Ted C Judd, et al.Clinical Pharmacology and Therapeutics|September 1, 2020
Time for a Fully Integrated Nonclinical-Clinical Risk Assessment to Streamline QT Prolongation Liability Determinations: A Pharma Industry PerspectiveHugo M Vargas, Michael G Rolf, Todd A Wisialowski, et al.Journal of Medicinal Chemistry|June 11, 2008
Design, synthesis, and evaluation of a novel 4-aminomethyl-4-fluoropiperidine as a T-type Ca2+ channel antagonistWilliam D Shipe, James C Barrow, Zhi-Qiang Yang, et al.Journal of Medicinal Chemistry|September 27, 2008
Discovery of 1,4-substituted piperidines as potent and selective inhibitors of T-type calcium channelsZhi-Qiang Yang, James C Barrow, William D Shipe, et al.Bioorganic & Medicinal Chemistry Letters|January 24, 2015
Development of 2-aminooxazoline 3-azaxanthenes as orally efficacious β-secretase inhibitors for the potential treatment of Alzheimer's diseaseJian Jeffrey Chen, Qingyian Liu, Chester Yuan, et al.Journal of Medicinal Chemistry|April 4, 2012
Design and synthesis of potent, orally efficacious hydroxyethylamine derived β-site amyloid precursor protein cleaving enzyme (BACE1) inhibitorsThomas A Dineen, Matthew M Weiss, Toni Williamson, et al.Pageof 7