Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Filters

Raymond P Baumann

Showing results (11-20 of 24) with videos related to

Pageof 3
Sort By:
Biochemical Pharmacology|December 17, 2009
Reductive activation of the prodrug 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine (KS119) selectively occurs in oxygen-deficient cells and overcomes O(6)-alkylguanine-DNA alkyltransferase mediated KS119 tumor cell resistanceRaymond P Baumann, Philip G Penketh, Kimiko Ishiguro, et al.
Chemical Research in Toxicology|July 12, 2014
Influence of glutathione and glutathione S-transferases on DNA interstrand cross-link formation by 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine, the active anticancer moiety generated by laromustinePhilip G Penketh, Eric Patridge, Krishnamurthy Shyam, et al.
Bioorganic & Medicinal Chemistry Letters|February 12, 2013
Chloroethylating and methylating dual function antineoplastic agents display superior cytotoxicity against repair proficient tumor cellsRui Zhu, Raymond P Baumann, Eric Patridge, et al.
Chemical Biology & Drug Design|May 5, 2012
A strategy for selective O(6)-alkylguanine-DNA alkyltransferase depletion under hypoxic conditionsPhilip G Penketh, Krishnamurthy Shyam, Raymond P Baumann, et al.
Analytical Biochemistry|May 19, 2016
When alcohol is the answer: Trapping, identifying and quantifying simple alkylating species in aqueous environmentsPhilip G Penketh, Krishnamurthy Shyam, Raymond P Baumann, et al.
Bioorganic & Medicinal Chemistry Letters|August 31, 2012
Design of a hypoxia-activated prodrug inhibitor of O6-alkylguanine-DNA alkyltransferaseRui Zhu, Helen A Seow, Raymond P Baumann, et al.
Journal of Cancer Therapy|August 16, 2013
Expression of <i>O</i><sup>6</sup>-Methylguanine-DNA Methyltransferase Examined by Alkyl-Transfer Assays, Methylation-Specific PCR and Western Blots in Tumors and Matched Normal TissueKimiko Ishiguro, Krishnamurthy Shyam, Philip G Penketh, et al.
Journal of Medicinal Chemistry|September 30, 2011
4-nitrobenzyloxycarbonyl derivatives of O(6)-benzylguanine as hypoxia-activated prodrug inhibitors of O(6)-alkylguanine-DNA alkyltransferase (AGT), which produces resistance to agents targeting the O-6 position of DNA guanineRui Zhu, Mao-Chin Liu, Mei-Zhen Luo, et al.
Journal of Medicinal Chemistry|January 23, 2015
Antitumor sulfonylhydrazines: design, structure-activity relationships, resistance mechanisms, and strategies for improving therapeutic utilityKrishnamurthy Shyam, Philip G Penketh, Raymond P Baumann, et al.
Archives of Toxicology|June 7, 2012
7-Nitro-4-(phenylthio)benzofurazan is a potent generator of superoxide and hydrogen peroxideEric V Patridge, Emma S E Eriksson, Philip G Penketh, et al.
Pageof 3

Showing results (11-20 of 24) with videos related to

Sort By:
Pageof 3
Biochemical Pharmacology|December 17, 2009
Reductive activation of the prodrug 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine (KS119) selectively occurs in oxygen-deficient cells and overcomes O(6)-alkylguanine-DNA alkyltransferase mediated KS119 tumor cell resistanceRaymond P Baumann, Philip G Penketh, Kimiko Ishiguro, et al.
Chemical Research in Toxicology|July 12, 2014
Influence of glutathione and glutathione S-transferases on DNA interstrand cross-link formation by 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine, the active anticancer moiety generated by laromustinePhilip G Penketh, Eric Patridge, Krishnamurthy Shyam, et al.
Bioorganic & Medicinal Chemistry Letters|February 12, 2013
Chloroethylating and methylating dual function antineoplastic agents display superior cytotoxicity against repair proficient tumor cellsRui Zhu, Raymond P Baumann, Eric Patridge, et al.
Chemical Biology & Drug Design|May 5, 2012
A strategy for selective O(6)-alkylguanine-DNA alkyltransferase depletion under hypoxic conditionsPhilip G Penketh, Krishnamurthy Shyam, Raymond P Baumann, et al.
Analytical Biochemistry|May 19, 2016
When alcohol is the answer: Trapping, identifying and quantifying simple alkylating species in aqueous environmentsPhilip G Penketh, Krishnamurthy Shyam, Raymond P Baumann, et al.
Bioorganic & Medicinal Chemistry Letters|August 31, 2012
Design of a hypoxia-activated prodrug inhibitor of O6-alkylguanine-DNA alkyltransferaseRui Zhu, Helen A Seow, Raymond P Baumann, et al.
Journal of Cancer Therapy|August 16, 2013
Expression of <i>O</i><sup>6</sup>-Methylguanine-DNA Methyltransferase Examined by Alkyl-Transfer Assays, Methylation-Specific PCR and Western Blots in Tumors and Matched Normal TissueKimiko Ishiguro, Krishnamurthy Shyam, Philip G Penketh, et al.
Journal of Medicinal Chemistry|September 30, 2011
4-nitrobenzyloxycarbonyl derivatives of O(6)-benzylguanine as hypoxia-activated prodrug inhibitors of O(6)-alkylguanine-DNA alkyltransferase (AGT), which produces resistance to agents targeting the O-6 position of DNA guanineRui Zhu, Mao-Chin Liu, Mei-Zhen Luo, et al.
Journal of Medicinal Chemistry|January 23, 2015
Antitumor sulfonylhydrazines: design, structure-activity relationships, resistance mechanisms, and strategies for improving therapeutic utilityKrishnamurthy Shyam, Philip G Penketh, Raymond P Baumann, et al.
Archives of Toxicology|June 7, 2012
7-Nitro-4-(phenylthio)benzofurazan is a potent generator of superoxide and hydrogen peroxideEric V Patridge, Emma S E Eriksson, Philip G Penketh, et al.
Pageof 3