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Journal of Medicinal Chemistry|November 25, 2011
Structure-guided evolution of potent and selective CHK1 inhibitors through scaffold morphingJohn C Reader, Thomas P Matthews, Suki Klair, et al.Nature|December 2, 2021
Footprint evidence of early hominin locomotor diversity at Laetoli, TanzaniaEllison J McNutt, Kevin G Hatala, Catherine Miller, et al.Science Translational Medicine|October 19, 2022
The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple Plasmodium kinases and life cycle stagesLauren B Arendse, James M Murithi, Tarrick Qahash, et al.Nature Communications|January 12, 2021
Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response BoxJanette Reader, Mariëtte E van der Watt, Dale Taylor, et al.Molecular Cancer Therapeutics|July 19, 2011
Potent, selective inhibitors of fibroblast growth factor receptor define fibroblast growth factor dependence in preclinical cancer modelsMatthew Squires, George Ward, Gordan Saxty, et al.Plos Pathogens|July 6, 2021
Early treatment with a combination of two potent neutralizing antibodies improves clinical outcomes and reduces virus replication and lung inflammation in SARS-CoV-2 infected macaquesKoen K A Van Rompay, Katherine J Olstad, Rebecca L Sammak, et al.Nature Microbiology|August 22, 2025
SARS-CoV-2 infection induces pro-fibrotic and pro-thrombotic foam cell formationDiana M Battaglia, Claire E Post, Wenbo Yao, et al.Journal of Medicinal Chemistry|May 12, 2016
Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737)James D Osborne, Thomas P Matthews, Tatiana McHardy, et al.Biorxiv : the Preprint Server for Biology|August 12, 2025
The Human Chk1 Inhibitor CHIR-124 Shows Multistage Activity Against Plasmodium falciparum via Dual Inhibition of PfArk1 and Hemozoin FormationKathryn J Wicht, John G Woodland, Larnelle F Garnie, et al.Biorxiv : the Preprint Server for Biology|July 18, 2020
SARS-CoV-2 infection induces germinal center responses with robust stimulation of CD4 T follicular helper cells in rhesus macaquesSonny R Elizaldi, Yashavanth Shaan Lakshmanappa, Jamin W Roh, et al.Pageof 109