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Cell Reports|April 26, 2018
Structural Basis for a Bimodal Allosteric Mechanism of General Anesthetic Modulation in Pentameric Ligand-Gated Ion ChannelsZaineb Fourati, Rebecca J Howard, Stephanie A Heusser, et al.EMBO Reports|July 15, 2025
A pivot-tether model for nucleosome recognition by the chromosomal passenger complexReinis R Ruza, Chyi Wei Chung, Danny B H Gold, et al.Medchemcomm|September 20, 2019
Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screenBenjamin N Atkinson, David Steadman, Yuguang Zhao, et al.Nature Communications|August 22, 2024
Structural insights into Frizzled3 through nanobody modulatorsJames Hillier, Yuguang Zhao, Loic Carrique, et al.Journal of Medicinal Chemistry|October 30, 2020
5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening HitWilliam Mahy, Nicky J Willis, Yuguang Zhao, et al.Journal of Medicinal Chemistry|August 14, 2020
Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase ActivityWilliam Mahy, Mikesh Patel, David Steadman, et al.ACS Chemical Neuroscience|June 22, 2022
Structural Analysis and Development of Notum Fragment Screening HitsYuguang Zhao, William Mahy, Nicky J Willis, et al.Journal of Medicinal Chemistry|May 10, 2022
Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment HitNicky J Willis, William Mahy, James Sipthorp, et al.Cell Host & Microbe|June 26, 2020
Neutralization of SARS-CoV-2 by Destruction of the Prefusion SpikeJiandong Huo, Yuguang Zhao, Jingshan Ren, et al.Nature Structural & Molecular Biology|July 15, 2020
Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2Jiandong Huo, Audrey Le Bas, Reinis R Ruza, et al.Pageof 2